A Higher Brain Circuit for Immediate Integration of Conflicting Sensory Information in Drosophila
A Higher Brain Circuit for Immediate Integration of Conflicting Sensory Information in Drosophila
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DOI：
10.1016/j.cub.2015.07.015
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发表时间：
2015-08-31
期刊：
影响因子：
9.2
通讯作者：
Kadow, Ilona C. Grunwald
中科院分区：
文献类型：
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作者：
Lewis, Laurence P. C.;Siju, K. P.;Kadow, Ilona C. Grunwald
动物不断评估感官信息，以决定下一步行动。然而，不同的感官线索往往需要相反的行为反应。大脑如何在决策过程中处理相互矛盾的感官信息？在这里，我们表明，苍蝇使用的神经基板归因于气味学习和记忆，包括蘑菇体（MB），立即感觉整合和先天行为的调制。黑腹果蝇必须整合矛盾的感官信息，在喂养发酵水果，释放食物的气味和先天厌恶的气味二氧化碳。在这里，使用这个框架，我们研究这种整合的神经基础。我们已经确定了一个局部回路，包括特定的多巴胺能输出和PAM多巴胺能输入神经元，在MB-β 2叶区域具有重叠的神经支配，其整合食物气味并抑制先天回避。食物气味反应性多巴胺能神经元的激活减少了由CO2反应性MB输出神经元介导的先天回避。我们假设，MB，除了其长期公认的作用，在学习和记忆，作为昆虫的大脑中心的即时感觉整合在瞬间决策。
Animals continuously evaluate sensory information to decide on their next action. Different sensory cues, however, often demand opposing behavioral responses. How does the brain process conflicting sensory information during decision making? Here, we show that flies use neural substrates attributed to odor learning and memory, including the mushroom body (MB), for immediate sensory integration and modulation of innate behavior. Drosophila melanogaster must integrate contradictory sensory information during feeding on fermenting fruit that releases both food odor and the innately aversive odor CO2. Here, using this framework, we examine the neural basis for this integration. We have identified a local circuit consisting of specific glutamatergic output and PAM dopaminergic input neurons with overlapping innervation in the MB-beta'2 lobe region, which integrates food odor and suppresses innate avoidance. Activation of food odor-responsive dopaminergic neurons reduces innate avoidance mediated by CO2-responsive MB output neurons. We hypothesize that the MB, in addition to its long recognized role in learning and memory, serves as the insect's brain center for immediate sensory integration during instantaneous decision making.