White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy.
White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy.
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DOI：
10.1002/hipo.22690
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发表时间：
2017-03
期刊：
影响因子：
3.5
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
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作者：
Fiford CM;Manning EN;Bartlett JW;Cash DM;Malone IB;Ridgway GR;Lehmann M;Leung KK;Sudre CH;Ourselin S;Biessels GJ;Carmichael OT;Fox NC;Cardoso MJ;Barnes J;Alzheimer's Disease Neuroimaging Initiative
本研究探讨脑白质高强度(WMH)体积、脑脊液(CSF)、阿尔茨海默病(AD)病理标记物以及脑和海马体体积丢失之间的关系。受试者包括198名对照组、345名轻度认知障碍(MCI)和154名AD受试者。测定脑脊液Aβ42和总tau(n=35 3)。使用边界移位积分(BSI)从序列MRI中定量脑和海马区的丢失。多元线性回归模型评估了WMHs与海马区和脑萎缩率的关系。在有脑脊液数据的受试者中，根据(A)并发的脑/海马体萎缩率和(B)脑脊液A、β、42和tau进行调整。WMH负荷与对照组(P=0.002.0 5)和轻度认知障碍组(P=0.0 3)的海马萎缩率呈正相关，与对照组的脑萎缩率(P=0.0 3)呈正相关。在调整了对照组和脑梗死组的并发脑萎缩率和对照组的脑脊液生物标志物后，与海马区萎缩的相关性仍然存在(P = 0.007)。这些新的结果表明，血管损伤和AD病理与非痴呆老年人中更大的海马区萎缩不成比例地相关。©2016作者海马体，由Wiley期刊出版公司出版。
This study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. Subjects included 198 controls, 345 mild cognitive impairment (MCI), and 154 AD subjects with serial volumetric 1.5‐T MRI. CSF Aβ42 and total tau were measured (n = 353). Brain and hippocampal loss were quantified from serial MRI using the boundary shift integral (BSI). Multiple linear regression models assessed the relationships between WMHs and hippocampal and brain atrophy rates. Models were refitted adjusting for (a) concurrent brain/hippocampal atrophy rates and (b) CSF Aβ42 and tau in subjects with CSF data. WMH burden was positively associated with hippocampal atrophy rate in controls (P = 0.002) and MCI subjects (P = 0.03), and with brain atrophy rate in controls (P = 0.03). The associations with hippocampal atrophy rate remained following adjustment for concurrent brain atrophy rate in controls and MCIs, and for CSF biomarkers in controls (P = 0.007). These novel results suggest that vascular damage alongside AD pathology is associated with disproportionately greater hippocampal atrophy in nondemented older adults. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.