Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease
Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease
复制标题
DOI：
10.1093/toxsci/kfu233
复制
发表时间：
2015-02-01
影响因子：
3.8
通讯作者：
Joshi-Barve, Swati
中科院分区：
文献类型：
--
作者：
Moghe, Akshata;Ghare, Smita;Joshi-Barve, Swati
丙烯醛是一种高活性的不饱和醛，是一种普遍存在的环境污染物，其对环境健康的潜在威胁已开始被认识到。除了内源性生成(新陈代谢和脂质过氧化)外，人类通过口服(食物和水)、呼吸(香烟烟雾、汽车尾气和杀菌剂使用)和皮肤途径接触丙烯醛。丙烯醛已被认为在几种疾病状态中发挥作用，包括脊髓损伤、多发性硬化症、阿尔茨海默病、心血管疾病、糖尿病以及神经、肝脏和肾脏毒性。在细胞水平上，丙烯醛暴露具有多种毒性效应，包括DNA和蛋白质内合、氧化应激、线粒体破坏、膜损伤、内质网应激和免疫功能障碍。本文综述了目前对丙烯醛毒性的各种致病机制的理解，重点介绍了已知的和预期的对临床疾病的贡献，以及潜在的治疗方法。
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant and its potential as a serious environmental health threat is beginning to be recognized. Humans are exposed to acrolein per oral (food and water), respiratory (cigarette smoke, automobile exhaust, and biocide use) and dermal routes, in addition to endogenous generation (metabolism and lipid peroxidation). Acrolein has been suggested to play a role in several disease states including spinal cord injury, multiple sclerosis, Alzheimer's disease, cardiovascular disease, diabetes mellitus, and neuro-, hepato-, and nephro-toxicity. On the cellular level, acrolein exposure has diverse toxic effects, including DNA and protein adduction, oxidative stress, mitochondrial disruption, membrane damage, endoplasmic reticulum stress, and immune dysfunction. This review addresses our current understanding of each pathogenic mechanism of acrolein toxicity, with emphasis on the known and anticipated contribution to clinical disease, and potential therapies.