Acupuncture prevents cognitive deficits and oxidative stress in cerebral multi-infarction rats
Acupuncture prevents cognitive deficits and oxidative stress in cerebral multi-infarction rats
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DOI：
10.1016/j.neulet.2005.09.049
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发表时间：
2006-01-23
影响因子：
2.5
通讯作者：
Han, JX
中科院分区：
文献类型：
--
作者：
Liu, CZ;Yu, JC;Han, JX
本研究旨在探讨针刺对多发性脑梗死大鼠认知功能障碍及氧化应激的影响。结果表明，针刺治疗可明显减轻多发性脑梗死所致的记忆障碍，表现为记忆障碍大鼠逃避潜伏期缩短，目标象限游泳时间增加。这些数据还表明，针刺治疗通过提高海马中超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性来改善脑多发性梗死诱导的氧化损伤。原位杂交和免疫组化结果显示，针刺可显著增加损伤大鼠海马CuZnSOD mRNA和蛋白的表达。结果表明，针刺对多发性脑梗死大鼠的空间记忆和抗氧化状态有改善作用。(C)2005爱思唯尔爱尔兰有限公司保留所有权利。
The aim of this study is to investigate the effects of acupuncture on cognitive deficits and oxidative stress in cerebral multi-infarction rats. The results showed that acupunctural treatment attenuated memory impairment induced by cerebral multi-infarction, as evaluated by shortened escape latency and increased swimming time of rats with memory impairment in the target quadrant. The data additionally suggested that acupunctural treatment ameliorated oxidative injuries induced by cerebral multi-infarction by increasing the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the hippocampus. Further investigation by in situ hybridization and immunohistochemistry revealed that acupunctural treatment significantly increased the expression of CuZnSOD mRNA and protein in the hippocampus of the impaired rats. The findings demonstrate that acupuncture can exert beneficial effects on spatial memory and antioxidant status of cerebral multi-infarction rats. (C) 2005 Elsevier Ireland Ltd. All rights reserved.