Acute tryptophan depletion as a model of depressive relapse - Behavioural specificity and ethical considerations
Acute tryptophan depletion as a model of depressive relapse - Behavioural specificity and ethical considerations
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DOI：
10.1192/bjp.187.2.148
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发表时间：
2005-08-01
影响因子：
10.5
通讯作者：
McNally, RJ
中科院分区：
文献类型：
--
作者：
Booij, L;Van Der Does, AJW;McNally, RJ
背景急性色氨酸缺失可短暂诱导缓解期抑郁症患者的症状。然而，行为特异性是不确定的。最近，症状激发研究已成为有争议的，特别是在美国。目的是评估急性色氨酸耗竭的特异性。去调查。系统的主观经验，那些参加症状激发study.Method 20个人缓解抑郁症进行了急性色氨酸耗竭的双盲，交叉试验。评估了与抑郁症相关的精神症状和自我图式。知情同意程序和主观经验的质量也evaluated.Results急性色氨酸耗竭引起特定的抑郁反应。这种影响在女性中比在男性中更明显。参与者对知情同意程序非常满意。他们明白，这是一个基础研究项目，不指望个人利益。然而，一些参与者仍然发现这是一个积极的experience.Conclusions急性色氨酸耗竭是一个合适的模型，从科学和伦理的角度来看，抑郁症的脆弱性。
Background Acute tryptophan depletion transiently induces symptoms in those with remitted depression. The behavioural specificity is uncertain, however. Recently, symptom provocation studies have become controversial, particularly in the USA.Aims To assess the specificity of acute tryptophan depletion. To investigate. systematically the subjective experiences of those taking part in a symptom provocation study.Method Twenty individuals with remitted depression underwent acute tryptophan depletion in a double-blind, crossover trial. Psychiatric symptoms and self-schemata relevant to depression were assessed. The quality of the informed consent procedure and subjective experiences were also evaluated.Results Acute tryptophan depletion induced a specific depressive response. The effects were more pronounced in females than in males. Participants were quite satisfied with the informed consent procedure. They had understood that this was a fundamental research project and personal benefits were not expected. However, some participants still found it a positive experience.Conclusions Acute tryptophan depletion is a suitable model of vulnerability to depression, from both a scientific and an ethical perspective.