Does areca nut use lead to dependence?
Does areca nut use lead to dependence?
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DOI：
10.1016/j.drugalcdep.2008.03.016
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发表时间：
2008-09-01
影响因子：
4.2
通讯作者：
Muralidharan, Kesavan
中科院分区：
文献类型：
--
作者：
Benegal, Vivek;Rajkumar, Ravi P.;Muralidharan, Kesavan
背景：槟榔的消费量约占世界人口的10%。而且，无论有没有烟草添加剂，其消费都与长期的健康风险有关。然而。目前尚不清楚它的使用是否与依赖综合征有关。目的：研究槟榔的使用(含或不含烟草添加剂)是否会导致依赖综合征的发生。方法：采用槟榔或槟榔+烟草制品使用核对表对三组人群进行系统评估：[a]使用不含烟草添加剂的槟榔制剂的人[n=98]；[b]使用含烟草添加剂的槟榔制剂的人[n=44]；以及[c]不使用槟榔或槟榔+烟草制品的人。使用模式。在使用者中存在依赖综合症。结果：槟榔组符合DSM-IV和ICD-10当前物质依赖定义的比例分别为38.8%和40.8%。根据DSM-IV和ICD-10标准，79.5%的槟榔+烟草组符合当前依赖使用的标准。这两组人都报告了清楚描述的戒断综合症和相似的使用效果的归因。结论：槟榔本身使用，与烟草添加剂一起使用效果更好。与相当数量的使用者的依赖综合症的发展有关。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
Background: The areca nut is consumed by approximately 10% of the world's population. and its consumption is associated with long-term health risks, with or without tobacco additives. However. it is not known whether its use is associated with a dependence syndrome. as is seen with other psychoactive substances.Objective: To examine whether areca nut usage (with or without tobacco additives) could lead to the development of a dependence syndrome.Methods: Three groups: [a] persons using areca nut preparations without tobacco additives [n=98]; [b] persons using areca nut preparations with tobacco additives [n=44]; and [c] 'Non-users' were systematically assessed using a checklist for the use of areca or areca+tobacco products. patterns of use. presence of a dependence syndrome in users. features of stimulant withdrawal and desired/beneficial effects.Results: 38.8% and 40.8% of the 'areca' group satisfied definitions of current substance-dependence according to DSM-IV and ICD-10 criteria respectively. 79.5% of the areca+tobacco group satisfied criteria for current dependent use according to both DSM-IV and ICD-10 criteria. Both the groups reported a well-delineated withdrawal syndrome and similar attributions for desirable effects of use.Conclusion: Areca nut use by itself and more so with tobacco additives. is associated with the development of a dependence syndrome in a substantial numbers of users. (C) 2008 Elsevier Ireland Ltd. All rights reserved.