Sake cake (sake-kasu) ingestion increases branched-chain amino acids in the plasma, muscles, and brains of senescence-accelerated mice prone 8
Sake cake (sake-kasu) ingestion increases branched-chain amino acids in the plasma, muscles, and brains of senescence-accelerated mice prone 8
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DOI：
10.1080/09168451.2019.1621155
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发表时间：
2019-05-24
影响因子：
1.6
通讯作者：
Matsubara, Kiminori
中科院分区：
文献类型：
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作者：
Izu, Hanae;Shibata, Sachi;Matsubara, Kiminori
为了检查清酒蛋糕摄入的代谢作用，在喂食清酒蛋糕饮食的加速衰老的小鼠8（SAMP 8）中分析血浆和组织。结果，发现清酒蛋糕组的血浆、腓肠肌和脑中的支链氨基酸（BCAA）显著高于对照组。清酒蛋糕组的小鼠比对照组显示出更强的握力。据报道，高水平的循环BCAA与病理状态有关，如代谢性疾病，但两组之间的葡萄糖和脂质代谢参数不受影响。除此之外，吡哆醛显著更高，烟酰胺以及1-甲基烟酰胺显示出在清酒蛋糕组的血浆中比对照组更高的趋势。这些发现表明，摄入清酒蛋糕增加了BCAA，维生素B-6和维生素B-3的水平。
To examine metabolic effects of sake cake ingestion, plasma and tissues were analyzed in senescence-accelerated mice prone 8 (SAMP8) fed a sake cake diet. As a result, branched-chain amino acids (BCAA) were found to be significantly higher in the plasma, gastrocnemius muscles and brains of the sake cake group than in the control group. Mice in the sake cake group showed stronger grip strength than the control group. High levels of circulating BCAA have been reported to be associated with pathological states, such as metabolic diseases, but the parameters of glucose and lipid metabolism were not affected between the two groups. Otherwise, pyridoxal was significantly higher and nicotinamide as well as 1-methylnicotinamide showed a tendency to be higher in the plasma of the sake cake group than in the control group. These findings indicate that intake of sake cake increases the levels of BCAA, vitamin B-6, and vitamin B-3.