Chromosomes and causation of human cancer and leukemia. XXII. Karyotypic changes in malignant melanoma
Chromosomes and causation of human cancer and leukemia. XXII. Karyotypic changes in malignant melanoma
复制标题
染色体与人类癌症和白血病的病因。
作者：
Phd SURABHI KAKATI;M. A. S. Y. SONG;MD AVERY A. SANDBERG;Roswell Park
对四种恶性黑色素瘤的细胞进行了详细的 G 和 C 显带核型分析。两个病例的众数在亚二倍体范围内，染色体数目从39到43不等。这两个肿瘤有5到13条标记染色体。另外两个肿瘤属于多倍体范围，染色体众数为 63 至 157 条。这些细胞有最少 11 条、最多 40 条标记染色体。 1 号染色体比任何其他染色体更容易发生畸变。该染色体上最常见的断点是 1q21、1q25 和 1q32。在各种染色体的着丝粒区域也发现了频繁的断点。然而，在 1 号染色体中，着丝粒区域似乎不参与其中。各种染色体上更常见的断点是 1q21、1q25、1q32、5p13、9q13、11q23、12q13。在这四例黑色素瘤中没有发现共同的标志物，但在不相关的肿瘤中注意到了共同的标志物。
Detailed karyotypic analysis with G‐ and C‐banding has been performed on cells of four malignant melanomas. The modal number in two cases was in the hypodiploid range, the chromosome numbers varying from 39 to 43. These two tumors had 5 to 13 marker chromosomes. The other two tumors were in the polyploid range, with modal numbers of 63 to 157 chromosomes. The cells had a minimum of 11 and a maximum of 40 marker chromosomes. Chromosome #1 was more frequently involved in aberrations than any other chromosome. The most common breakpoints on this chromosome were 1q21, 1q25 and 1q32. Frequent breakpoints were also noticed in the centromeric region in various chromosomes. In chromosome #1, however, the centromeric area does not seem to be involved. The more common breakpoints on the various chromosomes were 1q21, 1q25, 1q32, 5p13, 9q13, 11q23, 12q13. No common markers were noticed among these four cases of melanoma, but are noticed in unrelated tumors.