Distribution of virulence-associated genes in Vibrio mimicus isolates from clinical and environmental origins
Distribution of virulence-associated genes in Vibrio mimicus isolates from clinical and environmental origins
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DOI：
10.1111/j.1348-0421.2004.tb03551.x
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发表时间：
2004-01-01
影响因子：
2.6
通讯作者：
Shimada, T
中科院分区：
文献类型：
--
作者：
Shinoda, S;Nakagawa, T;Shimada, T
研究了拟态弧菌毒力相关基因的分布，包括毒素基因ctxA、tdh、st和vmh以及毒素产生调控基因toxR、toxS、toxT、tcpA和tcpP。大约一半的临床V mimicus分离株具有一个或多个基因编码V霍乱肠毒因子，如ctxA，tdh和ST。所有的临床和环境分离株具有VMH编码V mimicus溶血素（VMH）。ctxA基因仅在2株霍乱弧菌中检出，占临床分离株的5%。此外，具有ctxA表达所需的tcpP和toxT的菌株很少。这些结果可能表明，VMH是一个更重要的致病因素比公认的毒素，如霍乱毒素（CT）在V mimicus感染。
Distribution of virulence-associated genes in Vibrio mimicus was studied including the toxin genes ctxA, tdh, st and vmh and the genes necessary for regulation of toxin production, toxR, toxS, toxT, tcpA and tcpP. Approximately half of clinical V mimicus isolates possessed one or more genes encoding V cholerae enterotoxic factors such as ctxA, tdh and st. All of the clinical and environmental isolates possessed vmh encoding V mimicus hemolysin (VMH). The ctxA encoding cholera toxin was detected in only 2 strains, 5% of the clinical isolates. Furthermore, there were very few strains possessing tcpP and toxT needed for the expression of ctxA. These results may suggest that VMH is a more important pathogenic factor than well recognized toxins such as cholera toxin (CT) in V mimicus infection.