SALL4, the missing link between stem cells, development and cancer.
SALL4, the missing link between stem cells, development and cancer.
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DOI：
10.1016/j.gene.2016.02.019
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发表时间：
2016-06-15
期刊：
影响因子：
3.5
通讯作者：
Chai L
中科院分区：
文献类型：
--
作者：
Tatetsu H;Kong NR;Chong G;Amabile G;Tenen DG;Chai L
越来越多的证据支持癌细胞与胚胎干细胞（ESC）有许多相似之处。例如，侵袭性癌症和 ESC 具有共同的基因表达特征，其中包括数百个基因。由于 ESC 基因不存在于大多数成人组织中，因此它们可能是癌症特异性诊断和治疗的理想候选靶点。这是一个令人兴奋的癌症靶向模型。测试该模型的主要障碍是确定 ESC 内导致癌症表型的关键因素/途径。 SALL4 是少数能够建立这种联系的基因之一。 SALL4 的首次发表是关于其在具有多种发育缺陷的人类遗传性疾病中的突变。从那时起，已经发表了 300 多篇关于该基因在干细胞、发育和癌症方面的论文。本综述旨在总结我们目前对 SALL4 的了解，包括基于 SALL4 的癌症分类和靶向方法。关于这个重要基因的许多问题仍未得到解答，特别是该基因如何在分子水平上调节细胞命运。了解 SALL4 的分子功能将有助于在未来开发特定的靶向方法。
There is a growing body of evidence supporting that cancer cells share many similarities with embryonic stem cells (ESCs). For example, aggressive cancers and ESCs share a common gene expression signature that includes hundreds of genes. Since ESC genes are not present in most adult tissues, they could be ideal candidate targets for cancer-specific diagnosis and treatment. This is an exciting cancer-targeting model. The major hurdle to test this model is to identify the key factors/pathway(s) within ESCs that are responsible for the cancer phenotype. SALL4 is one of few genes that can establish this link. The first publication of SALL4 is on its mutation in a human inherited disorder with multiple developmental defects. Since then, over 300 papers have been published on various aspects of this gene in stem cells, development, and cancers. This review aims to summarize our current knowledge of SALL4, including a SALL4-based approach to classify and target cancers. Many questions about this important gene still remain unanswered, specifically, on how this gene regulates cell fates at a molecular level. Understanding SALL4’s molecular functions will allow development of specific targeted approaches in the future.