Retinal rods and cones have distinct G protein beta and gamma subunits.
Retinal rods and cones have distinct G protein beta and gamma subunits.
复制标题
视网膜视杆细胞和视锥细胞具有不同的G蛋白β和γ亚基。
DOI：
10.1073/pnas.89.22.10882
复制
发表时间：
1992
影响因子：
11.1
通讯作者：
Yau,KW
中科院分区：
文献类型：
--
作者：
Peng,YW;Robishaw,JD;Levine,MA;Yau,KW
Guanine nucleotide-binding proteins (G proteins) involved in transmembrane signal-transduction processes are heterotrimers composed of alpha, beta, and gamma subunits. The alpha subunit shows great diversity and is thought to confer functional specificity to a particular G protein. By contrast, the beta and gamma subunits appear much less diverse; in particular, the beta subunit is believed to have no role in G protein specificity. Using immunocytochemistry, we found distinct distribution patterns for different beta and gamma subunits in the retina. In particular, rod and cone photoreceptors, which both subserve phototransduction but differ in light-response properties, have different beta and gamma subunits in their outer segments. Thus, the G protein mediating phototransduction shows cell-specific forms of the beta and gamma subunits in addition to the alpha subunit. This surprising finding supports the hypothesis that these subunits may also contribute to functional specificity of a G protein.
