POSSIBLE RISK-FACTORS FOR SARCOIDOSIS - A CASE-CONTROL STUDY
POSSIBLE RISK-FACTORS FOR SARCOIDOSIS - A CASE-CONTROL STUDY
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DOI：
10.1111/j.1749-6632.1986.tb18540.x
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发表时间：
1986-06-06
影响因子：
5.2
通讯作者：
SOPER, K
中科院分区：
文献类型：
--
作者：
BRESNITZ, EA;STOLLEY, PD;SOPER, K
对结节病的描述最早出现在大约100年前的医学文献中。在过去的30年里，有许多关于结节病的流行病学研究表明，这种疾病的危险因素相对较少。公认的事实包括美国青年黑人人群中结节病的发病率较高；*.-‘疾病在家庭中聚集；女性发病率增加。然而，这种疾病的病因仍不清楚：几组研究人员已经使用病例对照方法来生成假说或测试结节病与可疑危险因素之间的关联的特定假说。1961年，Comstock等人报道了一项病例对照研究的结果，该研究旨在调查结节病的潜在病因。尽管这项研究没有提供明确的线索，但作者得出结论，病例对照研究设计是产生关于结节病病因的假设的有效方法。
Descriptions of sarcoidosis first appeared in the medical literature approximately 100 years ago.’During the last 30 years, there have been many epidemiological studies of sarcoidosis that have demonstrated relatively few risk factors for this disease. Accepted facts include a higher incidence of sarcoidosis in the young adult, black population in the United States;*.-’a clustering of disease in families; and an increased incidence in females. The etiology of the disease, however, remains unknown: Several groups of investigators have used the case-control method to either generate hypotheses or to test a specific hypothesis of an association between sarcoidosis and a suspected risk factor. In 1961, Comstock et aLS reported the results of a case-control study that was done to investigate potential etiologic factors for sarcoidosis. Although the study produced no definitive leads, the authors concluded that the case-control research design was a valid method to generate hypotheses concerning the etiology of sarcoidosis.