Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers
Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers
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DOI：
10.1016/s0006-291x(02)00920-8
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发表时间：
2002-08-23
影响因子：
3.1
通讯作者：
Lacal, JC
中科院分区：
文献类型：
--
作者：
Ramírez de Molina, A;Rodríguez-González, A;Lacal, JC
致癌作用是一个漫长的过程，导致主要在参与调节与细胞生长和细胞周期调节相关的信号传导途径的基因中积累遗传改变。调节细胞粘附和迁移、血管生成、凋亡和耐药性的其他基因的改变赋予癌细胞更恶性的表型。参与调节某些关键代谢途径的基因也在此过程中发生改变。胆碱激酶（ChoK）已被报道属于后一个癌症相关基因家族。最近，我们报道了在人类乳腺癌中观察到ChoK活性增加。在这里，我们提供了进一步的证据，ChoK失调是一个常见的事件，发现在各种人类肿瘤，如肺，结直肠和前列腺肿瘤。此外，当与适当的非致瘤性或原代细胞相比时，大量人肿瘤衍生细胞系也显示出增加的ChoK活性。这些发现强烈支持ChoK改变在人类肿瘤致癌过程中的作用，表明ChoK可用作肿瘤标志物。(C)2002 Elsevier Science（美国）。All rights reserved.
Carcinogenesis is a long process that results in the accumulation of genetic alterations primarily in genes involved in the regulation of signalling pathways relevant for the regulation of cell growth and the cell cycle. Alteration of additional genes regulating cell adhesion and migration, angiogenesis, apoptosis, and drug resistance confers to the cancer cells a more malignant phenotype. Genes that participate in the regulation of some critical metabolic pathways are also altered during this process. Choline kinase (ChoK) has been reported to belong to the latter family of cancer-related genes. Recently, we have reported that increased activity of ChoK is observed in human breast carcinomas. Here, we provide further evidence that ChoK dysregulation is a frequent event found in a variety of human tumors such as lung, colorectal, and prostate tumors. Furthermore, a large panel of human tumor-derived cell lines also show increased ChoK activity when compared to appropriate non-tumorigenic or primary cells. These findings strongly support the role of ChoK alterations in the carcinogenic process in human tumors, suggesting that ChoK could be used as a tumor marker. (C) 2002 Elsevier Science (USA). All rights reserved.