Assessment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)
Assessment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)
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DOI：
10.1007/bf03344184
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发表时间：
2006-09-01
影响因子：
5.4
通讯作者：
Cianfarani, S.
中科院分区：
文献类型：
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作者：
Federico, G.;Street, M. E.;Cianfarani, S.
GH缺乏症（GHD）的诊断是基于对药物刺激的GH反应峰值的测量。然而，药理学刺激缺乏精确性、准确性，不可再现，是侵入性的、非生理性的，并且一些甚至可能是危险的。此外，用于测量血清中GH的不同GH商业测定法的产率结果可能存在很大差异。与GH相反，IGF-I可以在单个随机获得的血液样本上测量。对现有数据的回顾表明，IGF-I测量在诊断儿童期发作的孤立性GHD中的特异性高达100%，灵敏度范围约为70%至90%。我们提出了一种算法，其中IGF-I的循环水平与生长发育学数据的评价，如生长速度和生长，可用于评估青春期前儿童GHD的可能性。
The diagnosis of GH deficiency (GHD) is based on the measurement of peak GH responses to pharmacological stimuli. Pharmacological stimuli, however, lack precision, accuracy, are not reproducible, are invasive, non-physiological and some may even be hazardous. Furthermore, different GH commercial assays used to measure GH in serum yield results that may differ considerably. In contrast to GH, IGF-I can be measured on a single, randomly-obtained blood sample. A review of the available data indicates that IGF-I measurement in the diagnosis of childhood-onset isolated GHD has a specificity of up to 100%, with a sensitivity ranging from about 70 to 90%. We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal children.