Maternal smoking during pregnancy and genetic polymorphisms in the Ah receptor, CYP1A1 and GSTM1 affect infant birth size in Japanese subjects
Maternal smoking during pregnancy and genetic polymorphisms in the Ah receptor, CYP1A1 and GSTM1 affect infant birth size in Japanese subjects
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DOI：
10.1093/molehr/gal013
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发表时间：
2006-02-01
影响因子：
4
通讯作者：
Kishi, R
中科院分区：
文献类型：
--
作者：
Sasaki, S;Kondo, T;Kishi, R
对烟草烟雾的遗传易感性可能与不良妊娠结局有关。为了评估母亲吸烟和基因多态性对婴儿出生体重和身长的影响，我们在日本札幌对293名分娩单胎活产婴儿的女性进行了一项前瞻性队列研究。在具有芳烃受体（AhR）野生型基因型（Arg/Arg；211克±76克；1.2厘米±0.4厘米，分别为p<0.01和p<0.01）、CYP1A1变异基因型（m1/m2 + m2/m2；170克±64克，0.8厘米±0.3厘米，分别为p<0.01和p<0.05）或谷胱甘肽S - 转移酶M1（GSTM1）缺失基因型（171克±58克，0.6厘米±0.3厘米，分别为p<0.01和p<0.05）的持续吸烟女性所生的婴儿中，出生体重和身长明显较低。当考虑这些基因型的组合时，在AhR野生型 + CYP1A1变异组（315克±116克；1.7厘米±0.6厘米，分别为p<0.01和p<0.01）以及CYP1A1变异 + GSTM1缺失组（237克±92克；1.3厘米±0.5厘米，分别为p<0.05和p<0.01）中，持续吸烟女性的婴儿出生体重和身长明显更低。这些基因型在从不吸烟的女性中没有不良影响；因此，母亲吸烟结合母亲的AhR、CYP1A1和GSTM1基因多态性可能对婴儿出生体型产生不良影响。
Genetic susceptibility to tobacco smoke might have relation to adverse pregnancy outcomes. To estimate the effects of maternal smoking and genetic polymorphisms on infant birth weight and length, we conducted a prospective cohort study of 293 women who delivered singleton live births in Sapporo, Japan. Birth weight and length were significantly lower among infants born to continuously smoking women having the aryl hydrocarbon receptor (AhR) wild type genotype (Arg/Arg; 211 g +/- 76 g; 1.2 cm +/- 0.4 cm, p < 0.01 and p < 0.01, respectively), the CYP1A1 variant genotype (m1/m2 + m2/m2; 170 g +/- 64 g, 0.8 cm +/- 0.3 cm, p < 0.01 and p < 0.05, respectively), or the GSTM1 null genotype (171 g +/- 58 g, 0.6 cm +/- 0.3 cm, p < 0.01 and p < 0.05, respectively). When combinations of these genotypes were considered, birth weight and length were significantly lower for infants of continuously smoking women in the AhR wild type + CYP1A1 variant group (315 g +/- 116 g; 1.7 cm +/- 0.6 cm, p < 0.01 and p < 0.01, respectively) and in the CYP1A1 variant + GSTM1 null group (237 g +/- 92 g; 1.3 cm +/- 0.5 cm, p < 0.05 and p < 0.01, respectively). These genotypes did not confer adverse effects among women who had never smoked; therefore, maternal smoking in combination with maternal AhR, CYP1A1 and GSTM1 genetic polymorphisms may adversely affect infant birth size.