ERPS TO RESPONSE PRODUCTION AND INHIBITION
ERPS TO RESPONSE PRODUCTION AND INHIBITION
复制标题
DOI：
10.1016/0013-4694(85)91017-x
复制
发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
KOPELL, BS
中科院分区：
文献类型：
--
作者：
PFEFFERBAUM, A;FORD, JM;KOPELL, BS
三个实验调查的影响，反应的产生和抑制的N2和P3成分的ERP [事件相关电位]的报告。在第一个实验中，12名年轻女性志愿者被呈现了“推”和“等待”（语义刺激）。在另一系列的试验中，他们看到了被赋予相同含义的任意符号（符号刺激）。对于每个刺激系列，一半的刺激被降解。为了获得数据可靠性的估计，重复每个任务。从Fz、Cz和Pz电极部位收集数据。P3振幅顶叶最大时，刺激指示受试者作出反应（去）。当刺激指示受试者保留反应（No-Go）时，中央和顶叶部位的P3相等。这种地形图获得了所有的刺激操作，简单和退化的刺激，文字和符号，并为第1和第2次运行。N2是一个额叶最大的组成部分，是更大的不去比去刺激。该结果对操作也具有稳健性。第二个实验研究了这些发现对明显运动反应的依赖性。符号和语义刺激系列分别呈现两次。受试者计数的Go刺激，不计数的No-Go刺激的一个演示和按下反应时间按钮，在实验1的其他演示。虽然计数（与按下按钮相比）延迟了N2和P3峰，但计数和按下按钮产生了类似的结果，包括Go/No-Go P3分布效应。第三个实验研究了这些发现对指示受试者响应或保留响应的符号方向的敏感性。结果模式对该操作具有稳健性。
Three experiments investigating the effects of response production and inhibition on the N2 and P3 components of the ERP [event-related potential] are reported. In the 1st experiment, 12 young female volunteers were presented with words ''push'' and ''wait'' (semantic stimuli). On a separate series of trials, they were presented with arbitrary symbols assigned the same meanings (symbolic stimuli). For each stimulus series half of the stimuli were degraded. To obtain an estimate of reliability of the data, each task was repeated. Data were collected from Fz, Cz and Pz electrode sites. The P3 amplitude had a parietal maximum when the stimuli instructed subjects to respond (Go). The P3 was equal at central and parietal sites when the stimuli instructed the subjects to withhold a response (No-Go). This topographic pattern was obtained for all stimulus manipulations, simple and degraded stimuli, words and symbols, and for the 1st and 2nd runs. The N2 was a frontal maximum component that was larger to the No-Go than to the Go stimuli. This result was also robust to the manipulations. A 2nd experiment investigated the dependency of these findings on an overt motor response. The symbolic and semantic stimulus series were each presented twice. The subjects counted the Go stimuli and did not count the No-Go stimuli for 1 presentation and pressed the reaction time button as in experiment 1 for the other presentation. While counting (compared to button pressing) delayed the N2 and P3 peaks, counting and pressing produced similar results, including the Go/No-Go P3 distribution effects. A 3rd experiment investigated the sensitivity of these findings to the orientation of the symbols instructing the subjects to respond or withhold the response. The pattern of results was robust to this manipulation.