Peripheral pulses of oxytocin increase partner preferences in female, but not male, prairie voles
Peripheral pulses of oxytocin increase partner preferences in female, but not male, prairie voles
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DOI：
10.1006/hbeh.1999.1558
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发表时间：
2000-02-01
影响因子：
3.5
通讯作者：
Carter, CS
中科院分区：
文献类型：
--
作者：
Cushing, BS;Carter, CS
中央管理催产素（OT）促进社会行为，包括合作伙伴的偏好，特点是一夫一妻制的草原田鼠社会系统。相比之下，外周管理OT通常在影响包括行为在内的中枢过程方面无效。OT从垂体后叶以脉冲形式释放到外周循环中。我们假设，外周给药OT，如果在重复注射模仿这些脉冲，将影响行为。雄性和雌性草原田鼠接受三次OT皮下注射，单次注射CT或等渗盐水。然后，将动物与指定为“伴侣”的异性成年成员一起同居1小时，随后测试对熟悉伴侣与可比较的陌生人的偏好。与对照组相比，接受外周OT脉冲（1、5或20 μ g）治疗的雌性动物对伴侣表现出明显的偏好，而接受较低剂量OT（0.1 μ g）或单次注射（20 μ g）的雌性动物则没有。也有一个显着的组内效应脉冲CT治疗的女性花更多的时间与合作伙伴相比，陌生人，而对照组女性花了等量的时间与合作伙伴和陌生人。外周脉冲OT不再有效地诱导合作伙伴的喜好时，女性进行了预处理的选择性OT受体拮抗剂，无论是外周或中央管理。与女性相比，外周治疗OT并没有促进男性的合作伙伴偏好的形成。(C)北京大学出版社.
Centrally administered oxytocin (OT) facilitates social behaviors including the partner preferences that characterize the monogamous social system of prairie voles. In contrast peripherally administered OT generally has been ineffective in influencing central processes including behavior. OT from the posterior pituitary gland is released in pulses into the peripheral circulation. We hypothesized that peripherally administered OT, if delivered in repeated injections mimicking these pulses, would influence behavior. Male and female prairie voles received three subcutaneous injections of OT, a single injection of CT, or isotonic saline. Animals then were placed with an adult member of the opposite sex, designated as a "partner," for a 1-h period of cohabitation, and subsequently tested for preference for the familiar partner versus a comparable stranger. Females treated with pulses of peripheral OT (1, 5, or 20 mu g) displayed a significant preference for the partner compared to control females, while females receiving a lower dose of OT (0.1 mu g) Or a single injection (20 mu g) did not. There was also a significant within-group effect as pulsed CT-treated females spent more time with the partner when compared to the stranger, while control females spent equal amounts of time with the partner and stranger. Peripheral pulses of OT were no longer effective in inducing partner preferences when females were pretreated with a selective OT receptor antagonist, administered either peripherally or centrally. In contrast to females, peripheral treatment with OT did not facilitate the formation of partner preferences in males. (C) 2000 Academic Press.