SELECTIVE ALTERATION OF MOUSE-BRAIN NEUROTRANSMITTER RELEASE WITH AGE
SELECTIVE ALTERATION OF MOUSE-BRAIN NEUROTRANSMITTER RELEASE WITH AGE
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DOI：
10.1016/0197-4580(87)90024-8
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发表时间：
1987-03-01
影响因子：
4.2
通讯作者：
GIBSON, GE
中科院分区：
文献类型：
--
作者：
FREEMAN, GB;GIBSON, GE
在年轻（3 个月）和年老（30 个月）Balb/c 小鼠中研究了不同脑区乙酰胆碱 (ACh)、谷氨酸 (GLU) 和多巴胺 (DA) 的释放。衰老增加了纹状体中 GLU (77%) 和 DA (29%) 以及海马体中 GLU (94%) 的基础释放； K+刺激后介质中这些神经递质的浓度不会因衰老而改变。尽管乙酰胆碱的基础释放不会因年龄而改变，但纹状体中 K+ 刺激的乙酰胆碱释放减少。基础 GLU 和 DA 释放与年龄相关的增加可能在衰老过程中细胞死亡的病理生理学中发挥重要作用。
The release of acetylcholine (ACh), glutamate (GLU) and dopamine (DA) from various brain regions was investigated in young (3 month) and old (30 month) Balb/c mice. Aging increased the basal release of GLU (77%) and DA (29%) in striatum and GLU in hippocampus (94%); the concentrations of these neurotransmitters in the media after K+ stimulation were unaltered by aging. Although the basal release of ACh was not altered by age, K+-stimulated ACh release was reduced in striatum. The age-related increases in basal GLU and DA release may be important in the pathophysiology of cell death during aging.