Multiple sporadic gastrointestinal stromal tumors (GISTs) of the proximal stomach are caused by different somatic KIT mutations suggesting a field effect
Multiple sporadic gastrointestinal stromal tumors (GISTs) of the proximal stomach are caused by different somatic KIT mutations suggesting a field effect
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DOI：
10.1097/pas.0b013e31817587ea
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发表时间：
2008-10-01
影响因子：
5.6
通讯作者：
Bihl, Michel P.
中科院分区：
文献类型：
--
作者：
Agaiwy, Abbas;Dirnhofer, Stephan;Bihl, Michel P.
Multifocal gastrointestinal stromal tumors (GISTs) are observed in patients with germline KIT or PDGFRA mutations, and in those with neurofibromatosis 1. However, the pathogenesis of apparently sporadic multifocal gastric GISTs in adults is poorly understood. We analyzed 27 GISTs from 11 patients (mean age, 75 y) with 2 to 4 tumors each. All tumors represented incidental findings in surgical (n = 8) and autopsy (n = 3) specimens and were located in the gastric body or fund us within
