Long-term effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin B12 concentrations
Long-term effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin B12 concentrations
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DOI：
10.1159/000052767
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发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
Naurath, HJ
中科院分区：
文献类型：
--
作者：
Henning, BF;Tepel, M;Naurath, HJ
背景：在老年人中，叶酸、钴胺素（维生素B-12）和磷酸吡哆醛（维生素Bg）缺乏是常见的。代谢产物同型半胱氨酸、甲基丙二酸、2-甲基柠檬酸和胱硫醚已被报道是这些维生素缺乏症的敏感标志物。目的：在49名具有正常维生素B-12水平的老年受试者中研究了含有1 mg维生素B-12、11 mg叶酸和5 mg维生素B-6的肌内维生素补充剂对高半胱氨酸（tHcy）、甲基丙二酸（MMA）、2-甲基柠檬酸（2-MCA）和胱硫醚（Cysta）的血清浓度的长期（269天）作用。研究方法：维生素补充剂在21天内施用8次，测量代谢物浓度直至第269天（例如，维生素补充剂结束后248天）。结果如下：从第0天到第21天，3种维生素的血清水平显著增加，停止补充后，在随访期内水平恢复到基线水平。MMA、2-MCA和tHcy水平在治疗期间显著降低，并且在248天内未达到基线值。治疗期间或治疗后，Cysta水平与基线无显著差异。结论：MMA和2-MCA水平更能反映维生素的利用率，尤其是钴胺素，而不是实际的血清水平。由于老年人缺乏叶酸、钴胺素和磷酸吡哆醛可能导致高同型半胱氨酸血症，因此可能对精神表现产生不利影响，因此测定老年精神障碍患者的MMA和2-MCA水平可能是改善或维持精神表现的一种具有成本效益的措施。版权所有（C）2001 S. Karger AG，巴塞尔。
Background: In the elderly, deficiencies of folate, cobalamin (vitamin B-12) and pyridoxal phosphate (vitamin Bg) are common. The metabolites homocysteine, methylmalonic acid, 2-methylcitric acid and cystathionine have been reported to be sensitive markers of these vitamin deficiencies. Objective: The long-term (269 days) effect of an intramuscular vitamin supplement containing 1 mg vitamin B-12, 1 1 mg folate, and 5 mg vitamin B-6 On serum concentrations of homocysteine (tHcy), methylmalonic acid (MMA), 2-methylcitric acid (2-MCA), and cystathionine (Cysta) was studied in 49 elderly subjects with normal levels of vitamin B-12. Methods: Vitamin supplement was administered 8 times over a 21-day period, metabolite concentrations were measured until day 269 (e.g. 248 days after the end of vitamin supplementation). Results: From day 0 to 21, the serum levels of the 3 vitamins increased significantly, after cessation of supplementation the levels returned to baseline within the follow-up period. The MMA, 2-MCA and tHcy levels decreased during the treatment period significantly and did not reach baseline values within the 248-day period. Cysta levels did not differ significantly from baseline, either during or after treatment. Conclusion: MMA and 2-MCA levels rather reflect the availability of vitamins, especially cobalamin, than the actual serum levels. Since deficiencies of folate, cobalamin and pyridoxal phosphate in the elderly may cause hyerhomocysteinemia and hence may have unfavorable effects on mental performance, determination of MMA and 2-MCA levels in elderly patients with mental disturbances may be a cost-effective measure to improve or maintain mental performance. Copyright (C) 2001 S. Karger AG,Basel.