Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis
Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis
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DOI：
10.1016/j.ajem.2020.05.073
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发表时间：
2020-09-01
影响因子：
3.6
通讯作者：
Lippi, Giuseppe
中科院分区：
文献类型：
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作者：
Henry, Brandon Michael;Aggarwal, Gaurav;Lippi, Giuseppe
2019冠状病毒病（COVID-19）感染现已达到大流行状态，影响全球100多万患者。需要紧急评估这些患者疾病结局的预测因素，以减少发病率和社会负担。乳酸脱氢酶（LDH）与病毒感染患者的不良预后相关。在对9项已发表的研究（n= 1532例COVID-19患者）的汇总分析中，我们评估了住院最早时间点测量的LDH水平升高与COVID-19患者疾病结局之间的关系。LDH水平升高与COVID-19患者发生严重疾病的几率增加约6倍，死亡率增加约16倍相关。需要更大规模的研究来证实这些发现。(c) 2020 Elsevier Inc.版权所有。
Coronavirus disease 2019 (COVID-19) infection has now reached a pandemic state, affecting more than a million patients worldwide. Predictors of disease outcomes in these patients need to be urgently assessed to decrease morbidity and societal burden. Lactate dehydrogenase (LDH) has been associated with worse outcomes in patients with viral infections. In this pooled analysis of 9 published studies (n= 1532 COVID-19 patients), we evaluated the association between elevated LDH levels measured at earliest time point in hospitalization and disease outcomes in patients with COVID-19. Elevated LDH levels were associated with a similar to 6-fold increase in odds of developing severe disease and a similar to 16-fold increase in odds of mortality in patients with COVID-19. Larger studies are needed to confirm these findings. (c) 2020 Elsevier Inc. All rights reserved.