Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease
Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease
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DOI：
10.1161/01.cir.0000031524.49139.29
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发表时间：
2002-09-03
期刊：
影响因子：
37.8
通讯作者：
Nishizawa, Y
中科院分区：
文献类型：
--
作者：
Jono, S;Ikari, Y;Nishizawa, Y
背景-骨保护素（OPG）是一种分泌性糖蛋白，属于肿瘤坏死因子受体家族。缺乏 OPG 的小鼠会出现严重的骨质疏松症以及主动脉和肾动脉的内侧动脉钙化。 OPG 免疫反应性在正常血管和早期动脉粥样硬化病变中得到证实。最近的一项临床研究表明，血清 OPG 水平升高与心血管死亡率之间存在显着相关性。我们检测了血清 OPG 水平是否与冠状动脉疾病 (CAD) 的进展相关。方法和结果 - 对 201 名因稳定胸痛而接受冠状动脉造影的患者进行了血清 OPG 水平检测。病变血管的数量用于代表 CAD 的严重程度。通过 ELISA 测量血清 OPG 水平，冠状动脉明显狭窄的患者的血清 OPG 水平显着高于无狭窄的患者。随着 CAD 严重程度的增加，血清 OPG 水平显着增加。对于冠状动脉正常或管腔不规则、1 支血管疾病、2 支血管的受试者，血清 OPG 水平为 0.94 +/- 0.34、1.04 +/- 0.38、1.19 +/- 0.38 和 1.44 +/- 0.54 ng/mL（中位值 0.91、0.99、1.09 和 1.37）疾病和三支血管疾病。多变量逻辑回归分析显示，血清 OPG 水平与 CAD 的存在显着相关[比值比，5.2； 95% 置信区间，1.7 至 16.0]。结论 - 我们的数据显示，血清 OPG 水平与 CAD 的存在和严重程度相关，表明 OPG 可能参与 CAD 的进展。
Background-Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family. OPG-deficient mice develop severe osteoporosis and medial arterial calcification of the aorta and renal arteries. OPG immunoreactivity was demonstrated in the normal blood vessels and in early atherosclerotic lesions. A recent clinical study suggests that there is a significant correlation between elevated serum OPG levels and cardiovascular mortality. We examined whether serum OPG levels are associated with the progression of coronary artery disease (CAD).Methods and Results-Serum OPG levels were examined in 201 patients who underwent coronary angiography because of stable chest pain. The number of diseased vessels was used to represent the severity of CAD. Serum OPG levels were measured by ELISA and were significantly greater in patients with significant stenosis of the coronary arteries than in those without stenosis. As the severity of CAD increased, there was a significant increase in serum OPG levels. Serum OPG levels were 0.94 +/- 0,34, 1.04 +/- 0.38, 1.19 +/- 0.38, and 1.44 +/- 0.54 ng/mL (medians 0.91, 0.99, 1.09, and 1.37) for the subjects with normal coronary arteries or luminal irregularities, 1-vessel disease, 2-vessel disease, and 3-vessel disease, respectively. Multivariate logistic regression analysis revealed that serum OPG levels were significantly associated with the presence of CAD [odds ratio, 5.2; 95% confidence interval, 1.7 to 16.0].Conclusions-Our data show that serum OPG levels are associated with the presence and severity of CAD, suggesting that OPG may be involved in the progression of CAD.