Exercise training increases creatine kinase capacity in canine myocardium.
Exercise training increases creatine kinase capacity in canine myocardium.
复制标题
运动训练可增加犬心肌中肌酸激酶的能力。
DOI：
10.1097/00005768-200101000-00015
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发表时间：
2001
影响因子：
4.1
通讯作者：
Mallet,RT
中科院分区：
文献类型：
--
作者：
Stuewe,SR;Gwirtz,PA;Mallet,RT
The creatine kinase (CK) energy shuttle of cardiomyocytes channels metabolic energy from the mitochondria to sites of energy utilization at contracting myofibrils and sarcolemmal and sarcoplasmic reticular ion pumps. Although plasticity of the myocardial CK system in response to hemodynamic overload has been repeatedly demonstrated, the effects of aerobic exercise training on myocardial CK are less well understood. This investigation tested the hypothesis that aerobic exercise training increases the capacity of the CK system in canine myocardium. Mongrel dogs were conditioned by a 9 wk treadmill running program or cage-rested for 4 wk. Total CK activity was measured spectrophotometrically; CKmb was isolated and measured by electrophoresis. Relative to sedentary controls, training increased left ventricular total CK activity 46%(P< 0.05), but did not alter total CK activity in right ventricular myocardium. Activity of the CKmb isoenzyme increased fourfold in left ventricular myocardium of trained vs. sedentary dogs (P< 0.05). The CK mb fraction of total CK activity in left ventricular myocardium increased 3-fold in response to training, from 1.1±0.4 to 3.4±0.8%,(P< 0.05). In contrast to left ventricle, CK mb activity and its fraction of total CK activity were not altered by training in right ventricular myocardium. Thus, aerobic exercise training increases total myocardial CK activity and the amount of CK mb present in canine left ventricular myocardium, although CK mb remains a minor component of the myocardial CK system.
