Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma.
Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma.
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发表时间：
1998-05
期刊：
影响因子：
11.2
通讯作者：
H. Takahashi;S. Ichimiya;Y. Nimura;M. Watanabe;M. Furusato;S. Wakui;R. Yatani;S. Aizawa;A. Nakagawara
中科院分区：
文献类型：
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作者：
H. Takahashi;S. Ichimiya;Y. Nimura;M. Watanabe;M. Furusato;S. Wakui;R. Yatani;S. Aizawa;A. Nakagawara
一个新的基因，p73，编码的蛋白质与p53具有显着的同源性，最近被确定在1p36。为探讨p73基因在前列腺癌发生发展中的作用，本研究对前列腺癌组织中p73基因突变、等位基因分型和转录水平进行了研究。在106例受检病例中未发现引起氨基酸替换或移码的突变类型。38例中有2例（5.3%）基因杂合性缺失。与正常组织相比，肿瘤中p73 α变体的表达水平不同。这些数据表明，p73基因并没有发挥重要作用，但p73的表达可能与前列腺癌的肿瘤生长。
A novel gene, p73, encoding a protein with significant homology to p53, was recently identified at 1p36. To investigate penetrance of p73 in prostatic carcinogenesis, mutation, allelotyping, and transcription analyses of p73 were performed in prostatic carcinoma. No types of mutation causing amino acid substitutions or frameshifts were found in 106 cases examined. Loss of heterozygosity in the gene was found in 2 of 38 cases (5.3%). Various expression levels of p73 alpha variant were observed in tumor compared with those in normal tissue. These data suggest that the p73 gene is not playing an essential role, but expression of p73 may associate with tumor growth in prostatic carcinogenesis.