Serial Propagation in vitro of Agents Producing Inclusion Bodies Derived from Varicella and Herpes Zoster.∗
Serial Propagation in vitro of Agents Producing Inclusion Bodies Derived from Varicella and Herpes Zoster.∗
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水痘和带状疱疹包涵体产生剂的体外连续繁殖。*
DOI：
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发表时间：
1953
期刊：
影响因子：
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通讯作者：
T. H. Weller
中科院分区：
文献类型：
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作者：
T. H. Weller
总结用来自水痘患者的囊泡液接种人体组织的滚管组织培养物，分离出6种致细胞病变因子。通过采用组织悬液作为传代材料，将其中两个菌株保持10次组织培养传代。在组织学上，产生的病变由细胞的局灶性积聚组成，这些细胞变得肿胀，然后退化;特征性地，这些细胞含有核内包涵体。从两例带状疱疹的发疹性病变中，分离出了性质相似的致细胞病变因子，并在人体组织培养物中连续繁殖。
Summary The inoculation of roller tube tissue cultures of human tissues with vesicle fluid derived from patients with varicella has resulted in the isolation of six cytopathogenic agents. Two of the strains have been maintained for 10 tissue culture passages by employing tissue suspensions as the passage material. Histologically the lesions produced consist of focal accumulations of cells which become swollen, and then degenerate; characteristically, such cells contain intranuclear inclusion bodies. From the eruptive lesions of two cases of herpes zoster, cytopathogenic agents of a similar nature have been isolated and have been propagated serially in cultures of human tissue.