Senescent no more.
Senescent no more.
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不再衰老。
DOI：
10.1111/pcmr.12939
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发表时间：
2021
影响因子：
4.3
通讯作者：
Arnheiter H
中科院分区：
文献类型：
--
作者：
Arnheiter H
老鼠和人类的雀巢的一个特点是，它们包含由雀巢细胞组成的“巢”，这些巢的大小和细胞数量可以通过各种形态测量手段来评估。它不仅适应了痣细胞中没有衰老特征的情况，而且也适应了这样一个事实，即生长受阻的痣在某些情况下可以重新启动生长并导致黑色素瘤。然而，鉴于组织微环境的众所周知的重要性，痣生长停滞很可能是由非痣细胞启动的，例如成纤维细胞，可以想象，这些细胞可能已经被衰老机制阻止了生长。[摘自文章]色素细胞和黑色素瘤研究的版权属于Wiley-Blackwell公司，其内容不得复制或通过电子邮件发送到多个网站或发布到列表服务器上，除非获得版权所有者的明确书面许可。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这篇摘要可以删节。对复制品的准确性不作任何保证。用户应参考该材料的原始出版版本，以获取完整摘要。版权适用于所有摘要。
A peculiarity of nevi in both mice and humans is that they contain" nests" of nevus cells, and the sizes and cell numbers of these nests can be assessed by various morphometric means. Not only does it accommodate the absence of a senescence signature in nevus cells but also the fact that growth-arrested nevi can reinitiate growth under certain circumstances and give rise to melanomas. Given the well-known importance of the tissue microenvironment, however, nevus growth arrest may well be initiated by non-nevus cells, such as fibroblasts, which conceivably may have become growth-arrested by senescence mechanisms.[Extracted from the article]Copyright of Pigment Cell & Melanoma Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.