Na(+) current in human ventricle: implications for sodium loading and homeostasis.
Na(+) current in human ventricle: implications for sodium loading and homeostasis.
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DOI：
10.1111/j.1540-8167.2006.00380.x
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发表时间：
2006-05-01
影响因子：
2.7
通讯作者：
Farley, Amanda L
中科院分区：
文献类型：
--
作者：
Makielski, Jonathan C;Farley, Amanda L
人体心室中的 Na 电流 (I(Na)) 通过心脏中电压门控 Na 通道的特定亚型进行传输。成孔α亚基由基因SCN5A编码。最多可以关联四个 β 亚基，并且较大的大分子复合物可能包括细胞骨架和支架蛋白的附着物，所有这些都可能影响电流的门控动力学。 I(Na) 是心脏动作电位启动和传播的基础，在心脏电生理学和心律失常中发挥着重要作用。此外，I(Na)还向心室细胞加载Na(+)离子，在细胞内Na稳态中发挥重要作用。这篇综述考虑了携带 I(Na) 的人类心脏 Na 通道的结构和功能，特别考虑了 I(Na) 的变化对获得性心脏病（如肥大、衰竭和缺血）的影响，这些疾病会影响 Na 负荷。
The Na current (I(Na)) in human ventricle is carried through a specific isoform of the voltage gated Na channel in heart. The pore forming alpha-subunit is encoded by the gene SCN5A. Up to four beta-subunits may be associated, and the larger macromolecular complex may include attachments to cytoskeleton and scaffolding proteins, all of which may affect the gating kinetics of the current. I(Na) underlies initiation and propagation of action potentials in the heart and plays a prominent role in cardiac electrophysiology and arrhythmia. In addition, I(Na) also loads the ventricular cell with Na(+) ions and plays an important role in intracellular Na homeostasis. This review considers the structure and function of the human cardiac Na channel that carries I(Na) with a particular consideration of the implications of alterations in I(Na) in acquired cardiac diseases such as hypertrophy, failure, and ischemia, which affect Na loading.