Plasma cell biology: Foundations for targeted therapeutic development in transplantation.
Plasma cell biology: Foundations for targeted therapeutic development in transplantation.
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浆细胞生物学：移植中靶向治疗发展的基础。
DOI：
10.1111/imr.13011
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发表时间：
2021-09
影响因子：
8.7
通讯作者：
Woodle ES
中科院分区：
文献类型：
--
作者：
Rossi AP;Alloway RR;Hildeman D;Woodle ES
实体器官移植是终末期器官疾病患者的救命手段。在过去的70年里，实体器官移植取得了巨大的进展，特别是在t细胞靶向免疫抑制和器官分配系统方面。然而，体液同种免疫反应仍然是进展的主要挑战。存在人类白细胞抗原（HLA）抗体的患者在接受匹配良好的器官方面处于明显的劣势，而且那些在移植后产生HLA抗体的患者面临着同种异体肾移植生存期的显著缩短。移植前脱敏或移植后抗菌素耐药性治疗的历史疗法效果有限，可能是因为它们不能显著降低抗体水平，因为抗体产生的来源浆细胞在很大程度上不受影响。在此，我们将讨论浆细胞在移植中的重要性，它们作为潜在治疗靶点的生物学方面，在开发移植靶浆细胞策略方面的临床挑战，以及有可能推动该领域发展的新方法。
Solid organ transplantation is a lifesaving procedure for patients with end-stage organ disease. Over the past 70 years, tremendous progress has been made in solid organ transplantation, particularly in T-cell targeted immunosuppression and organ allocation systems. However, humoral alloimmune responses remain a major challenge to progress. Patients with pre-existing antibodies to human leukocyte antigen (HLA) are at significant disadvantages in regard to receiving a well-matched organ, moreover those who develop anti-HLA antibodies after transplantation face a significant foreshortening of renal allograft survival. Historical therapies to desensitize patients prior to transplantation or to treat posttransplant AMR have had limited effectiveness, likely because they do not significantly reduce antibody levels as plasma cells, the source of antibody production, remain largely unaffected. Herein, we will discuss the significance of plasma cells in transplantation, aspects of their biology as potential therapeutic targets, clinical challenges in developing strategies to target plasma cells in transplantation, and lastly, novel approaches that have potential to advance the field.
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DOI：
10.1098/rspb.1954.0054
发表时间：
1954-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BILLINGHAM, RE;BRENT, L;MEDAWAR, PB
通讯作者：
MEDAWAR, PB
影响因子：
13.6
作者：
Aubert, Olivier;Loupy, Alexandre;Halloran, Philip F.
通讯作者：
Halloran, Philip F.
影响因子：
4.4
作者：
Cassese, G;Arce, S;Manz, RA
通讯作者：
Manz, RA
影响因子：
8.8
作者：
Bentall, A.;Cornell, L. D.;Stegall, M. D.
通讯作者：
Stegall, M. D.
影响因子：
8.8
作者：
Aparicio, Ricardo;Rana, Anil;Walker, David W.
通讯作者：
Walker, David W.