Drug abuse in schizophrenic patients: clinical correlates and reasons for use.
Drug abuse in schizophrenic patients: clinical correlates and reasons for use.
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精神分裂症患者的药物滥用：临床相关性和使用原因。
DOI：
10.1176/ajp.148.2.224
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Frances,AJ
中科院分区：
文献类型：
--
作者：
Dixon,L;Haas,G;Weiden,PJ;Sweeney,J;Frances,AJ
本研究的目的是：（1）确定精神分裂症、精神情感性精神分裂症和精神分裂症样精神分裂症患者的药物滥用流行率和偏好，（2）在住院期间的急性期和稳定期，对药物滥用和非药物滥用患者的人口统计学和临床变量进行比较，3）从病人那里获得关于药物滥用原因和中毒期间与急性状态有关的变化的数据。对连续入住纽约市教学医院的三名精神病住院患者进行评估。根据DSM-III-R的结构化临床访谈诊断为精神分裂症68例，情感障碍12例，精神分裂症型障碍3例。每个病人收到的简短精神病评定量表，全球评估量表，并在入院和出院时的阴性症状的评估量表，评估发病前的调整，和广泛的采访药物和酒精use.ResultsForty（48%）的患者接受诊断药物或酒精滥用或依赖。药物滥用患者主要使用大麻（N= 26），酒精（N= 21）和可卡因（N= 14），并报告他们滥用药物以获得“高”，以缓解抑郁和放松。他们有显着较少的阳性和阴性症状，在出院时，更好的性适应和更差的学校表现在青春期，和更多的家庭史ofdrug滥用比非d rugabusing patients.ConclusionsSchizophrenic患者滥用药物可能代表一个亚组的患者更好的治疗和不太严重的临床特征的精神分裂症，但他们的药物滥用可能会对全球的结果产生不利影响。
ObjectiveThis study aimed to 1) determine substance abuse prevalence and preference in a diverse sample ofschizophrenic, schizoaffective, and schizophreniform inpatients, 2) cornpare drug-abusing and non-drug-abusing patients on demographic and clinical variables during the acute and stabilization phases of their hospital course, and 3) obtain data from patients on reasons for drug abuse and on acute state-related changes during periods of intoxication.MethodEighty-three psychotic inpatients consecutively admitted to a New York City teaching hospital were evaluated. Sixty-eight had schizophrenia, 1 2 had schizo-affective disorder, and three had schizophreniforrn disorder diagnosed according to the Structured Clinical Interview for DSM-III-R. Each patient received ratings on the Brief Psychiatric Rating Scale, the Global Assessment Scale, and the Scale for the Assessment of Negative Symptoms at admission and at discharge, an evaluation of premorbid adjustment, and an extensive interview on drug and alcohol use.ResultsForty (48%) of the patients received diagnoses of drug or alcohol abuse or dependence. The drug-abusing patients primanly used cannabis(N= 26), alcohol(N= 2 1), and cocaine(N= I 4) and reported that they abused drugs to get “high,“to relieve depression, and to relax. They had significantly fewer positive and negative symptoms at discharge, better sexual adjustment and worse school performance during adolescence, and more family histories ofdrug abuse than the non-d rugabusing patients.ConclusionsSchizophrenic patients who abuse drugs may represent a subgroup of patients with better prognoses and less severe clinical characteristics of schiz-ophrenia, but their drug abuse may adversely affect global outcome.