Three-point technique of fat quantification of muscle tissue as a marker of disease progression in Duchenne muscular dystrophy: Preliminary study
Three-point technique of fat quantification of muscle tissue as a marker of disease progression in Duchenne muscular dystrophy: Preliminary study
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DOI：
10.2214/ajr.07.2732
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发表时间：
2008-01-01
影响因子：
5
通讯作者：
Gilsanz, Vicente
中科院分区：
文献类型：
--
作者：
Wren, Tishya A. L.;Bluml, Stefan;Gilsanz, Vicente
OBJECTIVE.涉及杜氏肌营养不良症患者的临床试验因缺乏合适的客观终点而受阻。本研究的目的是检查是否肌肉脂质浸润测量与三点狄克逊MRI技术作为一个标志物的疾病严重程度的价值。疾病的严重程度在9个男孩（平均年龄，8.6 +/- 2.7岁）与杜氏肌营养不良症是确定与布鲁克和同事的功能能力量表。将功能评分与下肢肌肉手动测试获得的力量测量值、等速测力计测量的膝伸肌力量以及三点狄克逊MRI技术测定的股四头肌和腘绳肌的肌肉脂肪百分比进行比较。MRI测量的脂肪浸润与功能等级的相关性（p < 0.05）比手动肌肉测试（p = 0.07）或等速测力计（p = 0.54）测量的定量强度更强。肌肉脂肪百分比与手动或测力计肌肉测试的力量测量值无关，但在杜氏肌营养不良症受试者中随年龄增加而增加。三点狄克逊磁共振成像获得的肌肉脂肪值在评估杜氏肌营养不良症患者的疾病严重程度方面是准确的。因为它们不受患者努力或检查者可变性的影响，这些测量比肌肉力量的测量更客观和可重复。
OBJECTIVE. Clinical trials involving patients with Duchenne muscular dystrophy are hindered by the lack of suitable objective end points. The purpose of this study was to examine whether muscle lipid infiltration measured with the three-point Dixon MRI technique has value as a marker of disease severity.SUBJECTS AND METHODS. Disease severity in nine boys (mean age, 8.6 +/- 2.7 years) with Duchenne muscular dystrophy was determined with the functional ability scale of Brooke and associates. Functional scores were compared with strength measurements obtained by manual testing of muscles of the lower extremities, knee extensor strength measured with an isokinetic dynamometer, and muscle fat percentage in the quadriceps and hamstrings determined with the three-point Dixon MRI technique.RESULTS. MRI measurements of fat infiltration had stronger correlation (p < 0.05) with functional grade than did measurements obtained with manual muscle testing (p = 0.07) or quantitative strength measured with the isokinetic dynamometer (p = 0.54). Muscle fat percentage did not correlate with strength measurements from manual or dynamometer muscle testing but increased with age in subjects with Duchenne muscular dystrophy.CONCLUSION. Muscle adiposity values obtained with three-point Dixon MRI are accurate in assessment of disease severity in patients with Duchenne muscular dystrophy. Because they are not influenced by patient effort or examiner variability, these measurements are more objective and reproducible than measurements of muscle strength.