Target concentration intervention: beyond Y2K
Target concentration intervention: beyond Y2K
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DOI：
10.1046/j.1365-2125.1999.00971.x
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发表时间：
1999-07-01
影响因子：
3.4
通讯作者：
Holford, NHG
中科院分区：
文献类型：
--
作者：
Holford, NHG
靶浓度干预（TCI）被提出作为治疗药物监测（TDM）的替代概念策略。有人认为，治疗范围的概念限制了对测量药物浓度的解释，并通过使用过于简化的药效学模型减少了患者的预期临床获益。另一方面，TCI包含药代动力学和药效学概念，并使用靶效应和相关靶浓度的概念来做出合理的个体剂量决定。
Target concentration intervention (TCI) is proposed as an alternative conceptual strategy to therapeutic drug monitoring (TDM). It is argued that the idea of a therapeutic range has limited the interpretation of measured drug concentrations and diminished the anticipated clinical benefit to patients by use of an oversimplified pharmacodynamic model. TCI on the other hand embraces pharmacokinetic and pharmacodynamic concepts and uses the idea of a target effect and associated target concentration to make rational individual dose decisions.