Elaborate Supramolecular Architectures Formed by Co-Assembly of Metal Species and Peptoid Macrocycles
Elaborate Supramolecular Architectures Formed by Co-Assembly of Metal Species and Peptoid Macrocycles
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DOI：
10.1021/acs.cgd.1c00209
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发表时间：
2021-05-18
影响因子：
3.8
通讯作者：
Kirshenbaum, Kent
中科院分区：
文献类型：
--
作者：
Jiang, Linhai;Hu, Chunhua Tony;Kirshenbaum, Kent
类肽是能够模拟多肽的结构和功能的序列特异性寡聚体家族。配位金属离子的存在可以增强类肽寡聚体的固有折叠和自组装能力。在这项工作中，我们探索了水溶性六聚体和四聚体类肽大环与Na+和K+离子的共组装。固态结构解决了六个cyclopeptoid金属coassemblies通过X-射线衍射使用单晶生长从完全水溶液。类肽低聚物组成的细微变化引起超分子组装体的巨大变化。一些结构具有广泛水合的多孔结构，包括不寻常的金属离子簇。在从水溶液获得的晶体中以原子分辨率研究金属类肽结构的能力是一个重要的进步，因为大多数以前的类肽晶体结构是从非水溶液或共溶剂溶液获得的。这些结果将有助于设计用于组装超分子框架的类肽和其他折叠体。
Peptoids are a family of sequence-specific oligomers capable of mimicking the structure and function of polypeptides. The innate folding and self-assembly capabilities of peptoid oligomers can be enhanced by the presence of coordinated metal ions. In this work, we explore the co-assembly of water-soluble hexameric and tetrameric peptoid macrocycles with Na+ and K+ ions. Solid-state structures were solved for six cyclopeptoid-metal coassemblies by X-ray diffraction using single crystals grown from fully aqueous solutions. Subtle variations in the peptoid oligomer composition give rise to dramatic alterations in the supramolecular assemblies. Some structures feature extensively hydrated porous architectures that include unusual metal ion clusters. The ability to study the metallopeptoid structure at an atomic resolution in crystals obtained from an aqueous solution is an important advancement, as most previous peptoid crystal structures were obtained from nonaqueous or cosolvent solutions. These results will facilitate the design of peptoids and other foldamers for the assembly of supramolecular frameworks.