Differences in insulin, growth hormone and pancreatic enzyme secretion after intravenous and intraduodenal administration of mixed amino acids in man.
Differences in insulin, growth hormone and pancreatic enzyme secretion after intravenous and intraduodenal administration of mixed amino acids in man.
复制标题
人类静脉内和十二指肠内施用混合氨基酸后胰岛素、生长激素和胰酶分泌的差异。
DOI：
10.1056/nejm197306072882302
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
E. Pfeiffer
中科院分区：
文献类型：
--
作者：
S. Raptis;H. Dollinger;K. Schröder;M. Schleyer;G. Rothenbuchner;E. Pfeiffer
为了确定肠道激素是否在氨基酸诱导的胰岛素、生长激素和胰酶的分泌中起生理学作用，对42名代谢正常的人进行了研究。静脉和十二指肠内注射氨基酸混合物(30g)。十二指肠内给药后血清胰岛素升高较高，且在氨基酸达到最大血药浓度之前。十二指肠内给药后，血糖、非酯化脂肪酸和游离甘油浓度下降更明显。给药途径对生长激素的血液浓度没有显著影响。十二指肠内注射氨基酸后，十二指肠液体积和碳酸氢盐含量略有增加，而胰酶和胆红素含量显著增加。这些结果表明，在人类口服氨基酸后，只有胰岛素的分泌明显受到肠道因素的影响。许多证据表明……
Abstract To determine whether intestinal hormones have a physiologic role in amino-acid-induced secretion of insulin, growth hormone and pancreatic enzymes, 42 metabolically normal human subjects were studied. An amino acid mixture (30 g) was administered intravenously and intraduodenally. A higher rise in serum insulin occurred after the intraduodenal application, and took place before the maximum blood concentration of amino acids was reached. Blood sugar, nonesterified fatty acids and free glycerol concentrations fell more clearly after intraduodenal administration. The route of administration did not significantly affect blood concentrations of growth hormone. After intraduodenal amino acids, the volume and bicarbonate contents of the duodenal juice rose slightly, whereas trypsin and bilirubin content increased considerably. These results suggest that, after oral administration of amino acids in man, only the secretion of insulin is clearly influenced by intestinal factors. Much evidence suggests that...