Androgen circle of polycystic ovary syndrome
Androgen circle of polycystic ovary syndrome
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DOI：
10.1093/humrep/dep049
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发表时间：
2009-07-01
影响因子：
6.1
通讯作者：
Homburg, Roy
中科院分区：
文献类型：
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作者：
Homburg, Roy
虽然多囊卵巢综合征（PCOS）的病因仍不清楚，寻找致病基因也很难，但人们普遍认为高雄激素血症是该综合征的核心。在这里，它提出，过剩的雄激素是PCOS的根本原因，从它们对女性胎儿在编程基因表达的影响开始，产生特征性的体征和症状，然后通过多个小卵泡的卵巢雄激素产生过剩的传播而加剧，在生殖寿命中无排卵和胰岛素抵抗，从而建立了雄激素过剩的恶性循环。这篇意见书，而不是一个全面的审查，是故意偏向于支持这一假设，雄激素过多是PCOS的“万恶之源”;希望它的接受可以导致更直接的治疗综合征的各个方面，而不是对症治疗雄激素过多的副作用，我们今天正在解决。
Although the aetiology of polycystic ovary syndrome (PCOS) is still not known and the search for causative genes is proving elusive, it is generally agreed that hyperandrogenism is at the heart of the syndrome. Here, it is proposed that excess androgens are the root cause of PCOS starting from their influence on the female fetus in programming gene expression, producing the characteristic signs and symptoms which are then exacerbated by a propagation of excess ovarian androgen production from multiple small follicles, anovulation and insulin resistance in the reproductive life-span, thus setting up a vicious perpetual circle of androgen excess. This opinion paper, rather than being a full-scale review, is intentionally biased in support of this hypothesis that androgen excess is the 'root of all evil' in PCOS; in the hope that its acceptance could lead to more direct treatment of the syndrome in all its facets rather than the symptomatic treatment of side effects of androgen excess that we are addressing today.