Efficacy predictors of a 2-month exclusive enteral nutrition for inducing remission of active Crohn's disease
Efficacy predictors of a 2-month exclusive enteral nutrition for inducing remission of active Crohn's disease
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2个月独家肠内营养诱导活动性克罗恩病缓解的疗效预测因素
DOI：
10.1038/s41430-018-0198-7
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发表时间：
2018
影响因子：
4.7
通讯作者：
Chen Yan
中科院分区：
文献类型：
--
作者：
Xue Meng;Zhang Hanyun;Wang Xiaoying;Xu Dingting;Jin Dan;Li Peiwei;Ye Jun;Yu Qiao;Chen Yan
目的探讨影响单纯肠内营养（EEN）治疗活动期CD疗效的因素。通过单变量和多变量分析，基线临床和实验室协变量与EEN治疗活动性CD（CDAI ≥150）的结局（临床缓解）相关。从连续136例活动性CD患者中共招募了67例。L4 b（Treitz韧带至回肠远端1/3）受累与临床缓解呈负相关（OR：0.14，OR：14.71），高血清白蛋白（≥35 g/L）与临床缓解呈正相关（OR：0.14，OR：14.71）。总之，L4 b保留和高血清白蛋白可能预测EEN治疗活动性CD的有利结局（ClinicalTrials.gov ID：NCT 02942511）。
In order to identify the factors that could predict the efficacy of exclusive enteral nutrition (EEN) in inducing remission of active CD. Baseline clinical and laboratory covariates were correlated with the outcome (clinical remission) of EEN in active CD (CDAI ≥150) by both univariable and multivariable analyses. A total of 67 from a consecutive of 136 active CD patients were enrolled. L4b (from treitz ligament to distal 1/3 ileum) involvement was negatively and high serum albumin (≥35 g/L) was positively associated with clinical remission (OR: 0.14, OR: 14.71). In conclusion, L4b sparing and high serum albumin might predict a favorable outcome of EEN in active CD (ClinicalTrials.gov ID: NCT 02942511).