Dry double-sided tape for adhesion of wet tissues and devices
Dry double-sided tape for adhesion of wet tissues and devices
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DOI：
10.1038/s41586-019-1710-5
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发表时间：
2019-11-07
期刊：
影响因子：
64.8
通讯作者：
Zhao, Xuanhe
中科院分区：
文献类型：
--
作者：
Yuk, Hyunwoo;Varela, Claudia E.;Zhao, Xuanhe
两个干燥的表面通过分子间力如氢键、静电相互作用和货车范德华相互作用（1，2）彼此接触后可立即粘附。然而，当涉及诸如身体组织的湿表面时，这种即时粘附是具有挑战性的，因为水分离两个表面的分子，从而防止相互作用（3，4）。尽管组织粘合剂具有优于缝合或钉合的潜在优点（5，6），但现有的液体或水凝胶组织粘合剂具有若干局限性：弱结合、低生物相容性、与组织的机械匹配差以及缓慢的粘合形成（5-13）。在这里，我们提出了一种替代组织粘合剂的形式，干双面胶带（DST）的生物聚合物（明胶或壳聚糖）和交联聚（丙烯酸）接枝N-氢化琥珀酰亚胺酯的组合制成。该DST的粘附机制依赖于从组织表面去除界面水，从而导致与表面的快速临时交联。随后与组织表面上的胺基团共价交联进一步改善DST的粘附稳定性和强度。体外小鼠、体内大鼠和离体猪模型表明，DST可以在5秒内实现各种湿动态组织与工程固体之间的强粘附。DST可用作组织粘合剂和密封剂，并可用于将可穿戴和可植入装置粘附到湿组织。
Two dry surfaces can instantly adhere upon contact with each other through intermolecular forces such as hydrogen bonds, electrostatic interactions and van der Waals interactions(1,2). However, such instant adhesion is challenging when wet surfaces such as body tissues are involved, because water separates the molecules of the two surfaces, preventing interactions(3,4). Although tissue adhesives have potential advantages over suturing or stapling(5,6), existing liquid or hydrogel tissue adhesives suffer from several limitations: weak bonding, low biological compatibility, poor mechanical match with tissues, and slow adhesion formation(5-13). Here we propose an alternative tissue adhesive in the form of a dry double-sided tape (DST) made from a combination of a biopolymer (gelatin or chitosan) and crosslinked poly(acrylic acid) grafted with N-hydrosuccinimide ester. The adhesion mechanism of this DST relies on the removal of interfacial water from the tissue surface, resulting in fast temporary crosslinking to the surface. Subsequent covalent crosslinking with amine groups on the tissue surface further improves the adhesion stability and strength of the DST. In vitro mouse, in vivo rat and ex vivo porcine models show that the DST can achieve strong adhesion between diverse wet dynamic tissues and engineering solids within five seconds. The DST may be useful as a tissue adhesive and sealant, and in adhering wearable and implantable devices to wet tissues.