Luteal phase defects induced by an agonist of luteinizing hormone-releasing factor: a model for fertility control.
Luteal phase defects induced by an agonist of luteinizing hormone-releasing factor: a model for fertility control.
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黄体生成素释放因子激动剂引起的黄体期缺陷：生育控制模型。
DOI：
10.1126/science.6797068
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Yen,SS
中科院分区：
文献类型：
--
作者：
Sheehan,KL;Casper,RF;Yen,SS
在正常的周期性妇女月经时连续三天皮下注射50微克促黄体生成素释放因子激动剂（LRF激动剂），诱导黄体期缩短，循环雌二醇和孕酮浓度低于最佳水平。这种黄体期缺陷是由于卵泡期促卵泡激素浓度降低，导致卵泡成熟不足。由于黄体期短与子宫内膜不利于着床有关，因此在月经周期开始时给予LRF激动剂可能被证明是一种实用且新颖的生育控制方法。
Subcutaneous injection of 50 micrograms of a luteinizing hormone-releasing factor agonist (LRF agonist) for three successive days at the time of menstruation in normal cycling women induces a shortened luteal phase with suboptimal concentrations of circulating estradiol and progesterone. This luteal phase defect follows a reduced concentration of follicle-stimulating hormone during the follicular phase and a resulting inadequate follicular maturation. Since a short luteal phase is associated with an endometrium not conducive to implantation, administration of the LRF agonist at the onset of menstrual cycle may prove to be a practical and novel approach to fertility control.