2-SUBSTITUTED CYCLOPROPYLAMINES .1. DERIVATIVES AND ANALOGS OF 2-PHENYLCYCLOPROPYLAMINE
2-SUBSTITUTED CYCLOPROPYLAMINES .1. DERIVATIVES AND ANALOGS OF 2-PHENYLCYCLOPROPYLAMINE
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DOI：
10.1021/jm01241a017
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发表时间：
1962-01-01
期刊：
影响因子：
--
通讯作者：
DAVIS, CS
中科院分区：
文献类型：
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作者：
KAISER, C;ZIRKLE, CL;DAVIS, CS
合成了一系列2-苯基环丙胺的类似物和衍生物，以研究其化学结构与单胺氧化酶抑制活性的关系。反式-2-苯基环丙胺4 5 '6是一种有效的单胺氧化酶（MAO）促进剂6和临床上有用的抗抑郁剂。为了研究结构对MAO抑制活性的影响，我们研究了该药物的许多类似物、同系物、异构体和衍生物。本文报道了它们的制备方法;它们的生物活性在下面的文章中介绍。
A series of analogs and derivatives of 2-phenylcyclopropylamine has been pre-pared in order to study relationships between chemical structure and monoamine oxidase inhibiting activity. traras-2-Phenylcyclopropylamine4 5’6 is a potent monoamine oxidase (MAO) inhibitor6and a clinically useful antidepressant agent. To investigate the effect of structure upon MAO inhibitory activity we have studied numerous analogs, homologs, isomers, andderivatives of this drug. Their preparation is reported in this paper; their biological activity is presented in the following article.