Effects of anabolic steroids on hormone-binding proteins, serum cortisol and serum nonprotein-bound cortisol.
Effects of anabolic steroids on hormone-binding proteins, serum cortisol and serum nonprotein-bound cortisol.
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合成代谢类固醇对激素结合蛋白、血清皮质醇和血清非蛋白结合皮质醇的影响。
DOI：
10.1210/jcem-32-2-232
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
R. Doe
中科院分区：
文献类型：
--
作者：
J. Barbosa;U. Seal;R. Doe
本文研究了口服和舌下注射17种α-甲基睾酮、丙酸睾丸酮、舌下含睾酮和含睾酮对血浆蛋白质的影响。观察甲状腺激素结合球蛋白(TBG)、甲状腺激素结合前白蛋白(TBPA)、皮质醇结合球蛋白(CBG)、血清皮质醇和非蛋白结合皮质醇(NPC)的变化。17种α烷基化合成类固醇引起的血压变化明显，总胆红素显著升高，总胆红素显著降低，羟美洛酮和美雄酮显著升高脑血糖值。后者在A环上都有共轭和不饱和的共振系统，而非17α烷基化的雄激素不会产生这些变化。没有乙基雌醇的C-3酮基似乎也..。
ABSTRACT The effects on plasma proteins of the anabolic steroids oxymetholone, methandrostenolone, stanozolol, fluoxymesterone, oxandrolone, norethandrolone, ethylestrenol, nandrolone phenpropionate and methandriol dipropionate, as well as 17α-methyltestosterone, given orally and sublingually, testosterone propionate sublingual and parenteral aqueous testosterone, were studied on both volunteers and patients. The responses of thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), cortisol-binding globulin (CBG), serum cortisol and nonprotein-bound cortisol (NPC) were studied. The 17α-alkylated anabolic steroids induced marked changes, with significant elevations of TBPA and depression of TBG; CBG was significantly increased by oxymetholone and methandrostenolone. Both the latter steroids have conjugated and unsaturated resonating systems in ring A. On the other hand, the non-17α-alkylated androgens did not produce these changes. The C-3 ketone group, absent from ethylestrenol, seemed also ...