OSTEOCYTE DEATH AND HIP FRACTURE
OSTEOCYTE DEATH AND HIP FRACTURE
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DOI：
10.1007/bf01673417
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发表时间：
1993-01-01
影响因子：
4.2
通讯作者：
GOLDSTEIN
中科院分区：
文献类型：
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作者：
DUNSTAN, CR;SOMERS, NM;GOLDSTEIN
骨细胞的活力可以通过其乳酸脱氢酶活性在骨的锯脱钙切片中证明。在股骨头的松质骨中，含有活骨细胞的骨陷窝比例从10-29岁时的88 +/- 7%（平均值+/- SD）下降到70-89岁时的58 +/- 12%（P < 0.001）。25-90岁受试者的第二腰椎活力为88 +/- 3%，并且没有随着年龄的增长而下降。21例年龄在72-94岁的髋部骨折患者的股骨头中的平均骨细胞活力为58 ± 21%，与相似年龄的对照组相似，尽管存在更大的变化，并且在5例患者中，骨细胞活力低于25%。在髋部骨折患者中，微骨折骨痂发生率与骨细胞活力呈正相关，如果骨活力低，则观察到很少或没有骨折骨痂。极限抗压强度与骨细胞活力无关。在股骨头中，骨细胞活力逐渐降低，这在髋部骨折中更为明显。骨细胞死亡可能通过损害疲劳损伤的修复而影响骨质量。
The viability of osteocytes can be demonstrated in sawn decalcified sections of bone by their lactate dehydrogenase activity. In the cancellous bone of the femoral head, the proportion of lacunae containing viable osteocytes decreased from 88 +/- 7% (mean +/- SD) at 10-29 years to 58 +/- 12% (P < 0.001) by 70-89 years. Viability in the second lumbar vertebra was 88 +/- 3% in subjects aged 25-90 years and did not decrease with age. Mean osteocyte viability in the femoral head of 21 hip fracture patients aged 72-94 years was 58 +/- 21%, similar to controls of a similar age, though there was greater variation and, in five patients, osteocyte viability was less than 25%. In hip fracture patients, microfracture callus incidence correlated positively with osteocyte viability, with little or no fracture callus observed if the bone viability was low. Ultimate compressive strength did not correlate with osteocyte viability. In the femoral head there is gradual, age-related reduction in osteocyte viability that can be more pronounced in hip fracture. Osteocyte death may affect bone quality by impairing repair of fatigue damage.