Formal Ir-Catalyzed Ligand-Enabled Ortho and Meta Borylation of Aromatic Aldehydes via in Situ-Generated Imines
Formal Ir-Catalyzed Ligand-Enabled Ortho and Meta Borylation of Aromatic Aldehydes via in Situ-Generated Imines
复制标题
DOI：
10.1021/jacs.5b11683
复制
发表时间：
2016-01-13
影响因子：
15
通讯作者：
Chattopadhyay, Buddhadeb
中科院分区：
文献类型：
--
作者：
Bisht, Ranjana;Chattopadhyay, Buddhadeb
本文报道了芳香醛的邻位和间位C-H硼化反应。根据设想，虽然邻位硼化可以使用叔丁胺作为无迹保护/导向基团来实现，但间位硼化通过催化剂配体和底物之间的静电相互作用和二次相互作用进行。这些配体与底物的静电相互作用和次级B-N相互作用为C-H活化/硼化提供了前所未有的控制因素。
The ligand-enabled development of ortho and meta C-H borylation of aromatic aldehydes is reported. It was envisaged that while ortho borylation could be achieved using tert-butylamine as the traceless protecting/directing group, meta borylation proceeds via an electrostatic interaction and a secondary interaction between the ligand of the catalyst and the substrate. These ligand substrate electrostatic interactions and secondary B-N interactions provide an unprecedented controlling factor for meta-selective C-H activation/borylation.