CONTROL OF THE RHESUS-MONKEY MENSTRUAL-CYCLE - PERMISSIVE ROLE OF HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE
CONTROL OF THE RHESUS-MONKEY MENSTRUAL-CYCLE - PERMISSIVE ROLE OF HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE
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DOI：
10.1126/science.6766566
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
MARSHALL, G
中科院分区：
文献类型：
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作者：
KNOBIL, E;PLANT, TM;MARSHALL, G
在患有下丘脑病变的恒河猴中（这似乎消除了促性腺激素释放激素的内源性产生），通过恒定的长期替代方案（包括每小时一次合成促性腺激素释放激素的静脉脉冲）重建正常的排卵月经周期。这一发现与以下假说雅阁：在整个月经周期中，垂体促性腺激素的分泌模式（基础分泌中断，平均每28天一次，由排卵前高峰引起）不是由下丘脑促性腺激素释放激素分泌的改变所决定的，而是由直接作用于垂体的卵巢雌激素的涨落所决定的。
In rhesus monkeys with hypothalamic lesions (which appear to abolish the endogenous production of gonadotropin-releasing hormone), normal ovulatory menstrual cycles were reestablished by an unvarying, long-term replacement regimen consisting of one intravenous pulse of synthetic gonadotropic-releasing hormone per hour. This finding is in accord with the hypothesis that the pattern of pituitary gonadotropin secretion throughout the menstrual cycle (basal secretion interrupted, once every 28 days on the average, by a preovulatory surge) is not directed by alterations in hypothalamic gonadotropic-releasing hormone secretion but by the ebb and flow of ovarian estrogens acting directly on the pituitary gland.