Contrasts in neuropsychological test profile between patients with first-episode schizophrenia and first-episode affective disorders
Contrasts in neuropsychological test profile between patients with first-episode schizophrenia and first-episode affective disorders
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DOI：
10.1111/j.1600-0447.1996.tb09830.x
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发表时间：
1996-08-01
影响因子：
6.7
通讯作者：
Mohr, F
中科院分区：
文献类型：
--
作者：
Albus, M;Hubmann, W;Mohr, F
对首发精神分裂症（FE）患者（n = 27）、单相抑郁症（n = 10）和双相情感障碍（n = 17）以及年龄和性别匹配的健康对照组（n = 27）进行了一系列神经心理学（NP）测试。FE精神分裂症患者在视觉运动处理和注意力方面的表现明显不如情感障碍患者。没有精神病特征的情感障碍患者与对照组的表现没有显著差异。然而，具有精神病特征的情感障碍患者的表现与精神分裂症患者一样差，其中视觉运动处理和注意力领域的损害最明显。我们的数据初步表明，存在一个二分法的神经心理障碍，精神病患者表现出类似的神经心理缺陷，而非精神病性情感患者执行的控制。
Patients with first-episode (FE) schizophrenia (n = 27), unipolar depression (n = 10) and bipolar disorder (n = 17) and age- and gender-matched healthy control subjects (n = 27) were administered a battery of neuropsychological (NP) tests. FE schizophrenics performed significantly less well than patients with affective disorders in the area of visual motor processing and attention. Affective disorder patients without psychotic features did not perform significantly differently to controls. However, affective disorder patients with psychotic features performed as poorly as schizophrenics, with the most pronounced impairment in the area of visual motor processing and attention. Our data tentatively suggest the existence of a dichotomy in neuropsychological impairment, with psychotic patients showing similar neuropsychological deficits, while non-psychotic affective patients perform comparably to controls.