The uptake of manganese in brain endothelial cultures
The uptake of manganese in brain endothelial cultures
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DOI：
10.1016/s0161-813x(02)00056-6
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发表时间：
2002-07-01
期刊：
影响因子：
3.4
通讯作者：
Mutkus, LA
中科院分区：
文献类型：
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作者：
Aschner, M;Shanker, G;Mutkus, LA
本研究重点关注磷酸锰和硫酸锰的石油中枢神经系统（CNS）运输动力学；这些发现与氯化锰 (MnCl2) 的传输动力学相关，氯化锰是先前研究过的一种模型锰化合物。进行了一系列研究来解决汇合培养的内皮细胞中锰盐的转运问题。大鼠脑内皮 (RBE4) 细胞培养物中锰盐（氯化物、硫酸盐和磷酸盐）的初始摄取率（5 废）具有盐依赖性，氯化锰和硫酸锰的摄取率最高（如与对照相比 Mn-54 的最大位移所反映）。磷酸锰的吸收率低于其他两种锰盐。这些数据表明脑内皮细胞有效转运硫酸锰。 (C) 2002 Elsevier Science Inc. 保留所有权利。
The present study focused oil central nervous system (CNS) transport kinetics of manganese phosphate and manganese sulfate; these findings were correlated with the transport kinetics of manganese chloride (MnCl2), a model Mn compound that has been previously studied. A series of studies was performed to address the transport of Mn salts in confluent cultured endothelial cells. The initial rate of uptake (5 ruin) of Mn salts (chloride, sulfate, and phosphate) in rat brain endothelial (RBE4) cell cultures is salt-dependent, with the highest rates of uptake for Mn chloride and Mn sulfate (as reflected by the greatest displacement of Mn-54 compared with control). Mn phosphate had a lower rate of uptake than the other two Mn salts. These data show that brain endothelial cells efficiently transport Mn sulfate. (C) 2002 Elsevier Science Inc. All rights reserved.