Artificial Allomelanin Nanoparticles
Artificial Allomelanin Nanoparticles
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DOI：
10.1021/acsnano.9b02160
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发表时间：
2019-10-01
期刊：
影响因子：
17.1
通讯作者：
Gianneschi, Nathan C.
中科院分区：
文献类型：
--
作者：
Zhou, Xuhao;McCallum, Naneki C.;Gianneschi, Nathan C.
异黑素是一种最常见于真菌中的无氮黑色素。它的存在增强了生物体对环境破坏的抵抗力，并有助于真菌在恶劣的辐射条件下生存，例如在航天器和受污染的核电站内发现的辐射条件。本文报道了1，8-二羟基萘（1，8-DHN）氧化聚合制备人工异黑素纳米颗粒（AMNPs）的方法和表征。我们描述了AMNPs的形态和大小控制，并证明它们是自由基清除剂。最后，我们表明，AMNPs采取了新生儿人表皮角质形成细胞和包装成核周帽，他们淬火后产生的活性氧暴露。
Allomelanin is a type of nitrogen-free melanin most commonly found in fungi. Its existence enhances resistance of the organisms to environmental damage and helps fungi survive harsh radiation conditions such as those found on spacecraft and inside contaminated nuclear power plants. We report the preparation and characterization of artificial allomelanin nanoparticles (AMNPs) via oxidative oligomerization of 1,8-dihydroxynaphthalene (1,8-DHN). We describe the resulting morphological and size control of AMNPs and demonstrate that they are radical scavengers. Finally, we show that AMNPs are taken up by neonatal human epidermal keratinocytes and packaged into perinuclear caps where they quench reactive oxygen species generated following UV exposure.