Structure of Rhodotorucine A, a Peptidyl Factor, Inducing Mating Tube Formation in Rhodosporidium toruloides
Structure of Rhodotorucine A, a Peptidyl Factor, Inducing Mating Tube Formation in Rhodosporidium toruloides
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红酵母A（一种肽因子，诱导圆红冬孢酵母交配管形成）的结构
DOI：
10.1271/bbb1961.43.363
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
S. Fukui
中科院分区：
文献类型：
--
作者：
Y. Kamiya;A. Sakurai;S. Tamura;Nobutaka Tkahashi;E. Tsuchiya;K. Abe;S. Fukui
Rhodotorucine A是一种由11个氨基酸残基组成、C端带有亲脂基的多肽，是一种诱导红景天交配管形成的新肽。通过Edman降解法和酶解法测定了该多肽的氨基酸序列。通过质子磁共振、质谱学和化学合成等手段，证明罗多托鲁辛A的C-末端为S-法尼基半胱氨酸。我们提出了以下结构，即Rhodotorucine A.H-Tyr-Pro-Glu-Ile-Ser-Trp-Thr-Arg-Asn-Gly-Cys(S-farnesyl)-OH.
Rhodotorucine A, which induces mating tube formation in Rhodospridium toruloides, was found to be a novel peptide composed of eleven amino acid residues with a lipophilic group at the C-terminus. The amino acid sequence of the peptide was determined by Edman degradation and enzymatic hydrolyses. The C-terminus of rhodotorucine A was revealed to be S-farnesylcysteine by proton magnetic resonance, mass spectrometry and chemical synthesis. We proposed the following structure for rhodotorucine A. H-Tyr-Pro-Glu-Ile-Ser-Trp-Thr-Arg-Asn-Gly-Cys(S-farnesyl)-OH.