Snoring and daytime sleepiness as risk factors for hypertension and diabetes in women - A population-based study
Snoring and daytime sleepiness as risk factors for hypertension and diabetes in women - A population-based study
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DOI：
10.1016/j.rmed.2006.10.015
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发表时间：
2007-06-01
影响因子：
4.3
通讯作者：
Janson, Christer
中科院分区：
文献类型：
--
作者：
Lindberg, Eva;Berne, Christian;Janson, Christer
本研究的目的是分析阻塞性呼吸暂停综合征（OSAS）的主要症状打鼾和白天过度嗜睡（EDS）是否与女性高血压和糖尿病相关。随机抽取6779名20-99岁的妇女，回答关于陡峭的障碍、日间症状和躯体疾病的问卷。这些妇女被分为四组：“没有EDS或打鼾”（参考组），“打鼾但没有EDS”，“EDS但没有打鼾”和“打鼾和EDS”。高血压和糖尿病的患病率在参照组中最低（分别为8.7%和1.6%），在打鼾和EDS的女性中最高（高血压：26.3%，糖尿病：5.8%）。在校正年龄、体重指数、吸烟、体力活动和酒精依赖的多变量模型中，“打鼾和EDS”是高血压的危险因素（校正OR 1.82（95%CI 1.30-2.55）），而单纯打鼾或EDS不是。在50岁以下的女性中，“打鼾和EDS”与高血压的关系更密切（adj. OR 3.41（1.78-6.54）vs. 1.50（1.02-2.19），P = 0.01）。对于糖尿病，“EDS但不打鼾”和“打鼾和EDS”都是危险因素，并且在年龄> 50岁的女性中相关性最明显（“EDS但不打鼾”的adj. OR 2.33（1.28-4.26）和“打鼾和EDS”的adj. OR 2.00（1.05-3.84））。我们的结论是打鼾和EDS的结合是女性高血压和糖尿病的危险因素。对于高血压，风险部分取决于年龄，对于糖尿病，EDS无打鼾是类似程度的风险因素。这些差异可能表明陡峭呼吸障碍与高血压和糖尿病之间的相关性的病理生理机制的差异。(c)2006爱思唯尔有限公司保留所有权利。
The aim of this study was to analyze whether snoring and excessive daytime sleepiness (EDS), the main symptoms of obstructive steep apnea syndrome (OSAS), are associated with hypertension and diabetes in women. A random sample of 6779 women aged 20-99 years answered questionnaires on steep disturbances, daytime symptoms and somatic diseases. The women were categorized into four groups: "no EDS or snoring" (reference group), "snoring but no EDS", "EDS but no snoring" and "snoring and EDS". Prevatences of hypertension and diabetes were lowest in the reference group (8.7% and 1.6%, respectively) and highest among women with both snoring and EDS (hypertension: 26.3%, diabetes: 5.8%). In a muttivariate model adjusting for age, body mass index, smoking, physical activity and alcohol dependency, "snoring and EDS" was a risk factor for hypertension (adjusted OR 1.82 (95% CI 1.30-2.55)) while isolated snoring or EDS was not. "Snoring and EDS" was more closely related to hypertension among women aged < 50 years (adj. OR 3.41 (1.78-6.54) vs. 1.50 (1.02-2.19), P = 0.01). For diabetes, both "EDS but no snoring" and "snoring and EDS" were risk factors and the associations were most pronounced in women aged > 50 years (adj. OR 2.33 (1.28-4.26) for "EDS but no snoring" and 2.00 (1.05-3.84) for "snoring and EDS"). We conclude that the combination of snoring and EDS is a risk factor for hypertension and diabetes in women. For hypertension, the risk is partly age dependent and, for diabetes, EDS without snoring is a risk factor of similar magnitude. These differences might indicate differences in pathophysiologic mechanisms underlying the association between steep-disordered breathing and hypertension and diabetes respectively. (c) 2006 Elsevier Ltd. All rights reserved.