Placental lipid transport and content in response to maternal overweight and gestational diabetes mellitus in human term placenta
Placental lipid transport and content in response to maternal overweight and gestational diabetes mellitus in human term placenta
复制标题
人类足月胎盘中胎盘脂质转运和含量对母亲超重和妊娠糖尿病的反应
DOI：
10.1016/j.numecd.2021.12.018
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发表时间：
2022-02-14
影响因子：
3.9
通讯作者：
Cui, Wei
中科院分区：
文献类型：
--
作者：
Song, Lin;Wang, Ning;Cui, Wei
背景和目的：妊娠前体重指数（pre-BMI）或妊娠期糖尿病（GDM）高的女性胎盘脂质转运发生改变，从而影响胎儿生长。然而，母体超重（OW）和GDM对胎盘脂质代谢和可能的适应的相互作用的研究较少。我们的目的是研究是否母亲OW或GDM是破坏人类足月胎盘中胎盘脂质加工的主要因素。
Background and aims: Placental lipid transport is altered in women with high prepregnancy body mass index (pre-BMI) or gestational diabetes (GDM), which consequently affects foetal growth. However, the interaction of maternal overweight (OW) and GDM on placental lipid metabolism and possible adaptations are less studied. We aimed to examine whether maternal OW or GDM is the main factor disrupting placental lipid processing in human term placenta.Methods and results: A total of 152 lean (18.5