Synthesis of allylanilines via scandium-catalysed benzylic C(sp3)-H alkenylation with alkynes
Synthesis of allylanilines via scandium-catalysed benzylic C(sp3)-H alkenylation with alkynes
复制标题
钪催化炔烃苄基 C(sp3)-H 烯基化合成烯丙基苯胺
DOI：
10.1039/d2cc02489f
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发表时间：
2022
影响因子：
4.9
通讯作者：
Hou Zhaomin
中科院分区：
文献类型：
--
作者：
Zhou Wei;Cong Xuefeng;Nishiura Masayoshi;Hou Zhaomin
首次在半夹心钪催化剂上实现了2-甲基叔苯胺与内炔的邻位选择性苄基C（sp ~ 3）-H烯基化反应。该方案提供了一个简单的路线，用于合成一个新的家庭2-烯丙基苯胺衍生物，具有广泛的底物范围，100%的原子效率，高产率，高化学，区域和立体选择性。
The ortho-selective benzylic C(sp3)–H alkenylation of 2-methyl tertiary anilines with internal alkynes has been achieved for the first time by using a half-sandwich scandium catalyst. This protocol provides a straightforward route for the synthesis of a new family of 2-allylaniline derivatives, featuring broad substrate scope, 100% atom-efficiency, high yields, and high chemo-, regio-, and stereoselectivity.