Effects of phencyclidine on active avoidance and escape in rats.
Effects of phencyclidine on active avoidance and escape in rats.
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苯环己哌啶对大鼠主动回避和逃避的影响。
DOI：
10.1007/bf00431717
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发表时间：
1985
影响因子：
3.4
通讯作者：
Norman,C
中科院分区：
文献类型：
--
作者：
Martin,P;Manning,M;Norman,C
在测试前，连续5天对接受过避免穿梭箱中电击训练的大鼠给予苯环己哌啶（0.0、1.0、5.0或10.0 mg/kg）。尽管动物在试验间隔期间继续越过屏障，但回避和逃避失败均呈剂量依赖性增加，表明它们能够做出适当的反应。在5天试验期间，几乎没有发现耐受性证据。
Rats trained to avoid electrical shock in a shuttle box were given phencyclidine (0.0, 1.0, 5.0, or 10.0 mg/kg) prior to testing for 5 consecutive days. There was a dose-dependent increase in both avoidance and escape failures although animals continued to cross the barrier during intertrial intervals, indicating that they were capable of making the appropriate response. Little evidence of tolerance was found during the 5-day testing period.